Structure of PDB 8wrb Chain R Binding Site BS01

Receptor Information
>8wrb Chain R (length=281) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIA
DLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFIS
LDRYIKINTTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYR
DKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNS
GKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKT
NEIMLVLSSFNSCLDPVMYFLMSSNIRKIMC
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain8wrb Chain R Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wrb Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174
Resolution2.91 Å
Binding residue
(original residue number in PDB)		Y135 F205 R286 Y289 N309 E310
Binding residue
(residue number reindexed from 1)		Y86 F147 R228 Y231 N251 E252
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wrb, PDBe:8wrb, PDBj:8wrb
PDBsum8wrb
PubMed38048360
UniProtQ9UPC5|GPR34_HUMAN Probable G-protein coupled receptor 34 (Gene Name=GPR34)

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