Structure of PDB 8tzq Chain R Binding Site BS01

Receptor Information
>8tzq Chain R (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVAT
LVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTA
VAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIA
NPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNRKLSQQKEKKA
TQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAV
NPIIYTTFNIEFRKAFLKIL
Ligand information
Ligand IDLDP
InChIInChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChIKeyVYFYYTLLBUKUHU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NCCc1ccc(O)c(O)c1
OpenEye OEToolkits 1.5.0c1cc(c(cc1CCN)O)O
ACDLabs 10.04Oc1ccc(cc1O)CCN
FormulaC8 H11 N O2
NameL-DOPAMINE;
DOPAMINE
ChEMBLCHEMBL59
DrugBankDB00988
ZINCZINC000000033882
PDB chain8tzq Chain R Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tzq A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D114 V115 C118 S193 F389 H393
Binding residue
(residue number reindexed from 1)		D79 V80 C83 S158 F218 H222
Annotation score4
External links
PDB RCSB:8tzq, PDBe:8tzq, PDBj:8tzq
PDBsum8tzq
PubMed39103320
UniProtP14416|DRD2_HUMAN D(2) dopamine receptor (Gene Name=DRD2)

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