Structure of PDB 8t3s Chain R Binding Site BS01

Receptor Information
>8t3s Chain R (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLT
LADLLLLLLLPFKIIEAASNLPKVVCALTSFGFYSSIYCSTWLLAGISIE
RYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLCYENFT
DNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPGAQRRRRAV
GLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPL
LFYFSSSV
Ligand information
Ligand IDBUA
InChIInChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)
InChIKeyFERIUCNNQQJTOY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CCCC(=O)O
CACTVS 3.385CCCC(O)=O
FormulaC4 H8 O2
Namebutanoic acid
ChEMBLCHEMBL14227
DrugBankDB03568
ZINCZINC000000895132
PDB chain8t3s Chain R Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8t3s Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Resolution3.07 Å
Binding residue
(original residue number in PDB)		Y90 C141 R180 Y238 H242 R255
Binding residue
(residue number reindexed from 1)		Y84 C135 R161 Y217 H221 R234
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t3s, PDBe:8t3s, PDBj:8t3s
PDBsum8t3s
PubMed38198545
UniProtO15552|FFAR2_HUMAN Free fatty acid receptor 2 (Gene Name=FFAR2)

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