Structure of PDB 8iz4 Chain R Binding Site BS01

Receptor Information
>8iz4 Chain R (length=281) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIAD
LLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISL
DRYIKINTTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRD
KHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSG
KYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTN
EIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQ
Ligand information
Ligand IDTJR
InChIInChI=1S/C21H43O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h20,22H,2-19H2,1H3,(H2,24,25,26)/t20-/m1/s1
InChIKeyLAYXSTYJRSVXIH-HXUWFJFHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O)O
CACTVS 3.385CCCCCCCCCCCCCCCCCC(=O)OC[CH](O)CO[P](O)(O)=O
CACTVS 3.385CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CO[P](O)(O)=O
OpenEye OEToolkits 2.0.7CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)O)O
FormulaC21 H43 O7 P
Name[(2~{R})-2-oxidanyl-3-phosphonooxy-propyl] octadecanoate
ChEMBL
DrugBank
ZINC
PDB chain8iz4 Chain R Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8iz4 Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors
Resolution2.93 Å
Binding residue
(original residue number in PDB)		G131 T132 A182 R208 N220 L223
Binding residue
(residue number reindexed from 1)		G81 T82 A123 R149 N161 L164
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iz4, PDBe:8iz4, PDBj:8iz4
PDBsum8iz4
PubMed
UniProtQ9UPC5|GPR34_HUMAN Probable G-protein coupled receptor 34 (Gene Name=GPR34)

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