Structure of PDB 8iw4 Chain R Binding Site BS01

Receptor Information
>8iw4 Chain R (length=296) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CIKSSYAPWPRAILYGVLGLGALLAVFGNLLVIIAILHFKQLHTPTNFLV
ASLACADFLVGVTVMPFSTVRSVESCWYFGESYCKFHTCFDTSFCFASLF
HLCCISIDRYIAVTDPLTYPTKFTVSVSGLCIALSWFFSVTYSFSIFYTG
ANEEGIEELVALTCVGGCQAPLNQNWVLLCFLLFFLPTVVMVFLYGRIFL
VAKYQARKIEGYKERVAKRERKAAKTLGIAMAAFLVSWLPYIIDAVIDAY
MNFITPAYVYEILVWCVYYNSAMNPLIYAFFYPWFRKAIKLIVSGK
Ligand information
Ligand IDSPD
InChIInChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChIKeyATHGHQPFGPMSJY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CCNCCCN)CN
ACDLabs 10.04NCCCNCCCCN
CACTVS 3.341NCCCCNCCCN
FormulaC7 H19 N3
NameSPERMIDINE;
N-(2-AMINO-PROPYL)-1,4-DIAMINOBUTANE;
PA(34)
ChEMBLCHEMBL19612
DrugBankDB03566
ZINCZINC000001532612
PDB chain8iw4 Chain R Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8iw4 Structural basis of amine odorant perception by a mammal olfactory receptor.
Resolution3.49 Å
Binding residue
(original residue number in PDB)		D112 T113 F168 Y274 V300
Binding residue
(residue number reindexed from 1)		D91 T92 F147 Y241 V267
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001594 trace-amine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0008227 G protein-coupled amine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iw4, PDBe:8iw4, PDBj:8iw4
PDBsum8iw4
PubMed37225986
UniProtQ5QD04|TAAR9_MOUSE Trace amine-associated receptor 9 (Gene Name=Taar9)

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