Structure of PDB 8hqm Chain R Binding Site BS01

Receptor Information
>8hqm Chain R (length=307) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFEESRIVLVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLAL
CELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCI
SCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQTEDKETC
FDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQ
KAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGAMCGLEERLYTA
SVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLT
HSRDTEE
Ligand information
Ligand ID140
InChIInChI=1S/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22)
InChIKeyKVTFEOAKFFQCCX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(NCC(=O)O)CCCCCCCCCCCCCCC
OpenEye OEToolkits 1.5.0CCCCCCCCCCCCCCCC(=O)NCC(=O)O
CACTVS 3.341CCCCCCCCCCCCCCCC(=O)NCC(O)=O
FormulaC18 H35 N O3
NameN-PALMITOYLGLYCINE;
N-HEXADECANOYLGLYCINE
ChEMBLCHEMBL226117
DrugBankDB03440
ZINCZINC000008689962
PDB chain8hqm Chain R Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hqm Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		H106 E184 T185 Q191 E283 Y287
Binding residue
(residue number reindexed from 1)		H70 E148 T149 Q155 E244 Y248
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hqm, PDBe:8hqm, PDBj:8hqm
PDBsum8hqm
PubMed37770763
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q9UNW8

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