Structure of PDB 8hn8 Chain R Binding Site BS01

Receptor Information
>8hn8 Chain R (length=276) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STRITLAFLMSLLAFAIMLGNAVVILAFVVDKNLRHRSNYFFLNLAISDF
FVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDR
YQSVSNAVSYRTQHTGILKIVTLMVAVWVLAFLVNGPMILVSESWKDEGS
ECEPGFFSEWYILAITSFLEFLVPVILVAYFNMYIYWSLWKRGHLELLRA
RKLAKSLAILLGVFAVCWAPYSLFTIVLSFYPSATRPKSVWYRIAFWLQW
FNSFVNPFLYPLCHKRFQKAFLKIFC
Ligand information
Ligand IDHSM
InChIInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKeyNTYJJOPFIAHURM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1c(nc[nH]1)CCN
CACTVS 3.341NCCc1c[nH]cn1
ACDLabs 10.04n1c(cnc1)CCN
FormulaC5 H9 N3
NameHISTAMINE
ChEMBLCHEMBL90
DrugBankDB05381
ZINCZINC000000388081
PDB chain8hn8 Chain R Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hn8 Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D94 Y95 C98 F344 Q347
Binding residue
(residue number reindexed from 1)		D82 Y83 C86 F246 Q249
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0008150 biological_process
GO:0022900 electron transport chain
GO:0043408 regulation of MAPK cascade
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042597 periplasmic space
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hn8, PDBe:8hn8, PDBj:8hn8
PDBsum8hn8
PubMed
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q9H3N8|HRH4_HUMAN Histamine H4 receptor (Gene Name=HRH4)

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