Structure of PDB 8hcq Chain R Binding Site BS01

Receptor Information

>8hcq Chain R (length=303) Species: 9606 (Homo sapiens)

HNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGP
NALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQ
KSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFI
LAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFC
MPLVCTAIFYTLMTCEMLNLSEHLKQRREVAKTVFCLVVIFALCWFPLHL
SRILKKTVYEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKK
FKN

Ligand information

>8hcq Chain L (length=21) Species: 9606 (Homo sapiens)

CSCSSLMDKECVYFCHLDIIW

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8hcq Structural basis of peptide recognition and activation of endothelin receptors.
• Resolution: 3.01 Å
• Binding residue (original residue number in PDB): Q72 N137 K140 G144 Q165 K166 Y231 T238 Q252 L259 W319 R326 M336 L344 L348 D351
• Binding residue (residue number reindexed from 1): Q7 N72 K75 G79 Q100 K101 Y166 T173 Q187 L194 W245 R252 M261 L269 L273 D276

Enzymatic activity

• Enzyme Commision number: 1.13.12.13: Oplophorus-luciferin 2-monooxygenase.

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004962 endothelin receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008217 regulation of blood pressure
• GO:0042310 vasoconstriction
• GO:0048484 enteric nervous system development

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8hcq, PDBe:8hcq, PDBj:8hcq
• PDBsum: 8hcq
• PubMed: 36882417
• UniProt: P25101|EDNRA_HUMAN Endothelin-1 receptor (Gene Name=EDNRA)