Structure of PDB 8e3z Chain R Binding Site BS01

Receptor Information
>8e3z Chain R (length=372) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLA
CPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQ
TMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISF
ILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLV
EGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGC
WDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSP
YSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVA
ILYCFLNGEVQAELRRKWRRWH
Ligand information
>8e3z Chain P (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
HSDAVFTDNYTRLRKQMAVKKYLNSILN
Receptor-Ligand Complex Structure
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PDB8e3z Understanding VPAC receptor family peptide binding and selectivity
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E36 C37 F90 Y118 D132 T136 Y139 Y146 K195 F200 E204 F222 V226 D287 T288 I289 W294 M370 E373 L374
Binding residue
(residue number reindexed from 1)		E1 C2 F55 Y83 D97 T101 Y104 Y111 K160 F165 E169 F187 V191 D252 T253 I254 W259 M335 E338 L339
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e3z, PDBe:8e3z, PDBj:8e3z
PDBsum8e3z
PubMed36385145
UniProtP32241|VIPR1_HUMAN Vasoactive intestinal polypeptide receptor 1 (Gene Name=VIPR1)

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