Structure of PDB 8cwo Chain R Binding Site BS01

Receptor Information
>8cwo Chain R (length=67) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVVPIKTVHIGAVDYKDTALLRKFISERGKIRARRVTGLSVQDQRKVAIA
IKNARELALLPYASTAR
Ligand information
>8cwo Chain A (length=1034) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaa
cacaugcaagucgaacggaaaggcccuuggggugcucgaguggcgaacgg
gugaguaacacgugaguaaccugcccuugacuuugggauaacuucaggaa
acuggggcuaauaccggauaggagcuccugcugcaugguggggguuggaa
aguuucggcgguuggggauggacucgcggcuuaucagcuuguuggugggg
uaguggcuuaccaaggcuuugacggguagccggccugagagggugaccgg
ccacauugggacugagauacggcccagacuccuacgggaggcagcagugg
ggaauauugcacaaugggcggaagccugaugcagcaacgccgcgugcggg
augacggccuucggguuguaaaccgcuuucgccugugacgaagcgugagu
gacgguaauggguaaagaagcaccggcuaacuacgugccagcagccgcgg
ugauacguagggugcgagcguuguccggauuuauugggcguaaagggcuc
guaggugguugaucgcgucggaaguguaaucuuggggcuuaacccugagc
gugcuuucgauacggguugacuugaggaagguaggggagaauggaauucc
ugguggagcgguggaaugcgcagauaucaggaggaacaccaguggcgaag
gcgguucucugggccuuuccugacgcugaggagcgaaagcguggggagcg
aacaggcuuagauacccugguaguccacgcuguaaacgguggguacuagg
ugugggguccauuccacggguuccgugccguagcuaacgcuuuaaguacc
ccgccuggggaguacggccgcaaggcuaaaacucaaaggaauuacacacc
gcccgucaagucaugaaaguugguaacacccgaagccgguggccuaaccg
uugugggggagccgucgaaggugggacuggugauuaggacuaagucguaa
caagguagccguaccggaaggugcggcuggauca
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<..<<.<<<..>>>...>>>..>>>>>......
<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<...
.>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>....
.<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<..
.......>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.
........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>...<<<<<<<......<<....>>
.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>..
.....>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<
...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>.
..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<
<<<<<..<<<......>>>.....>>>>>>>>>...........<<....
>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<.
..<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<
<<<<<<<<<<.<...>.>>>>>>>>>>>>..<<<..))>>>....>>>>>
>.>>>.<<<......<<<<....>>>>....>>>..)))).]........
<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<..
....>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...
>.....<<<<<<<<<....>>>>>>>>>......
Receptor-Ligand Complex Structure
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PDB8cwo Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		K14 H17 K38 I39 A41 R42 Q50 Q52 R53 A56 I57 K60 N61 R63 E64 Y70
Binding residue
(residue number reindexed from 1)		K6 H9 K30 I31 A33 R34 Q42 Q44 R45 A48 I49 K52 N53 R55 E56 Y62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cwo, PDBe:8cwo, PDBj:8cwo
PDBsum8cwo
PubMed36864821
UniProtQ6A5N1|RS18_CUTAK Small ribosomal subunit protein bS18 (Gene Name=rpsR)

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