Structure of PDB 8c6j Chain R Binding Site BS01

Receptor Information

>8c6j Chain R (length=76) Species: 9606 (Homo sapiens)

MYNGIGLPTPRGSGTNGYVQRNLSLVRPNPDILDHERKRRVELRCLELEE
MMEEQGYEEQQIQEKVATFRLMLLEK

Ligand information

>8c6j Chain 5 (length=113)

acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagau
uuccguggagaggaacaacucugagucuuaacccaauuuuuugagccuug
ccuuggcaaggcu

<<<<.<<<<<<<<<<<<........<<<<<<<<...........>>>>>>
>>...>>>>>>>>>>>....>.>>>>.................<<<<<<<
<....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c6j Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): R11 G12
• Binding residue (residue number reindexed from 1): R11 G12

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0005515 protein binding
• GO:0070742 C2H2 zinc finger domain binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0015030 Cajal body
• GO:0016607 nuclear speck
• GO:0071005 U2-type precatalytic spliceosome
• GO:0071007 U2-type catalytic step 2 spliceosome
• GO:0071013 catalytic step 2 spliceosome

External links

• PDB: RCSB:8c6j, PDBe:8c6j, PDBj:8c6j
• PDBsum: 8c6j
• PubMed: 36867703
• UniProt: Q9UQ35|SRRM2_HUMAN Serine/arginine repetitive matrix protein 2 (Gene Name=SRRM2)