Structure of PDB 7yfe Chain R Binding Site BS01

Receptor Information
>7yfe Chain R (length=1255) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMILTQFGPFIESISGITDQSNDVFENAAKAFSMFTRSDVYKALDEIPFS
EDAMLPIPPTIYTKPSHDSYYYIDALNRVRRKTYQGPDDVYVPNCSIVEL
LEPHETLTSYGRLSEAIENRAKDGDSQARIATTYGRIAESQARQIKAPLE
KFVLALLVAEAGGSLYDPVLQKYDEIPGLSHNCPLWCFREICRHISGPLP
DRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQQTAGLDPSLVRL
GVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLEGGYCPNLEWLEP
RSDYKFMYMGAMPLSTKYARSAPSNDKKARELGEKYGLSSVVSELRRRTK
TYSKHDFTSVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQK
DWTGPIGEIRILKDTTSSIARYLYRTWYLAAARMAAQPRTWDPLFQAIMR
SQYVTARGGSGATLRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPF
SHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYH
MNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVI
MAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLS
KLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETF
LTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVNSET
IQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVG
KERANSSAEEPWPAILDQIMGIFFNGVHDGLQWQRWIRYSWALCCAFSRQ
RTGYLQYPMWSFVYWGLPLVKVFGSDPWIFSWYMPTGDLGMYSWISLIRP
LMTRWMVANGYVTDKCSPVFGNADYRKCFNELKLYQGYYMAQLPRNPKKS
GRAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPS
LFDVPHKWYQGAQEAATATREELAEMDETLMRARKHSYSSFSKLLEAYLL
VKWRMCEAREPSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQ
TLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADAL
AGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDTMFKHHVKLLPKDGRHLN
TDIPPRMGWLRAILRFLGAGMAMTATGVAVDIYLEDIHGGGRSLGQRFMT
WMRQE
Ligand information
Receptor-Ligand Complex Structure
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PDB7yfe In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R526 S561 K566 K783 R797
Binding residue
(residue number reindexed from 1)		R524 S559 K564 K781 R795
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0032774 RNA biosynthetic process
Cellular Component
GO:0019013 viral nucleocapsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yfe, PDBe:7yfe, PDBj:7yfe
PDBsum7yfe
PubMed36469786
UniProtC9E870

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