Structure of PDB 7yed Chain R Binding Site BS01

Receptor Information
>7yed Chain R (length=1254) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMILTQFGPFIESISGITDQSNDVFENAAKAFSMFTRSDVYKALDEIPFS
EDAMLPIPPTIYTKPSHDSYYYIDALNRVRRKTYQGPDDVYVPNCSIVEL
LEPHETLTSYGRLSEAIENRAKDGDSQARIATTYGRIAESQARQIKAPLE
KFVLALLVAEAGGSLYDPVLQKYDEIPGLSHNCPLWCFREICRHISGPLP
DRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQQTAGLDPSLVRL
GVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLEGGYCPNLEWLEP
RSDYKFMYMGAMPLSTKYARSAPSNDKKARELGEKYGLSSVVSELRRRTK
TYSKHDFTSVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQK
DWTGPIGEIRILKDTTSSIARYLYRTWYLAAARMAAQPRTWDPLFQAIMR
SQYVTARGGSGATLRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPF
SHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYH
MNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVI
MAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLS
KLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETF
LTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVNSET
IQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVG
KERANSSAEEPWPAILDQIMGIFFNGVHDGLQWQRWIRYSWALCCAFSRQ
RGYLQYPMWSFVYWGLPLVKVFGSDPWIFSWYMPTGDLGMYSWISLIRPL
MTRWMVANGYVTDKCSPVFGNADYRKCFNELKLYQGYYMAQLPRNPKKSG
RAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPSL
FDVPHKWYQGAQEAATATREELAEMDETLMRARKHSYSSFSKLLEAYLLV
KWRMCEAREPSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQT
LFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALA
GKIMLQDVNTVQLARVVNLAVPDTWMSLDFDTMFKHHVKLLPKDGRHLNT
DIPPRMGWLRAILRFLGAGMAMTATGVAVDIYLEDIHGGGRSLGQRFMTW
MRQE
Ligand information
>7yed Chain M (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuaaaaauuuuaaaauaauu
.....................
Receptor-Ligand Complex Structure
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PDB7yed In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G560 L782 K783 R797 H798 N827 R1103 K1104 Y1105 A1107 Q1108 T1109 K1114 S1117 L1119 D1120 V1121 T1169 R1214 W1217
Binding residue
(residue number reindexed from 1)		G558 L780 K781 R795 H796 N825 R1094 K1095 Y1096 A1098 Q1099 T1100 K1105 S1108 L1110 D1111 V1112 T1160 R1205 W1208
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0032774 RNA biosynthetic process
Cellular Component
GO:0019013 viral nucleocapsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yed, PDBe:7yed, PDBj:7yed
PDBsum7yed
PubMed36469786
UniProtC9E870

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