Structure of PDB 7xta Chain R Binding Site BS01

Receptor Information
>7xta Chain R (length=283) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLL
VSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDR
YYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIID
LIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVT
AKEHAHQITKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTA
FLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC
Ligand information
Ligand IDSRO
InChIInChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChIKeyQZAYGJVTTNCVMB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc2c(cc1O)c(c[nH]2)CCN
ACDLabs 10.04Oc1cc2c(cc1)ncc2CCN
CACTVS 3.341NCCc1c[nH]c2ccc(O)cc12
FormulaC10 H12 N2 O
NameSEROTONIN;
3-(2-AMINOETHYL)-1H-INDOL-5-OL
ChEMBLCHEMBL39
DrugBankDB08839
ZINCZINC000000057058
PDB chain7xta Chain R Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7xta GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D99 T103 C195 F274 F275 N278
Binding residue
(residue number reindexed from 1)		D82 T86 C178 F229 F230 N233
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0030594 neurotransmitter receptor activity
GO:0046872 metal ion binding
GO:0099589 serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0022900 electron transport chain
GO:0030277 maintenance of gastrointestinal epithelium
GO:0032098 regulation of appetite
GO:0070254 mucus secretion
GO:0098664 G protein-coupled serotonin receptor signaling pathway
GO:0120056 large intestinal transit
GO:0150052 regulation of postsynapse assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042597 periplasmic space
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xta, PDBe:7xta, PDBj:7xta
PDBsum7xta
PubMed35714614
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q13639

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