Structure of PDB 7x5h Chain R Binding Site BS01

Receptor Information
>7x5h Chain R (length=274) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDV
LVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL
DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSE
GSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSREQK
EQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYS
NSFFNPLIYTAFNKNYNSAFKNFF
Ligand information
Ligand ID8K3
InChIInChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
InChIKeyWKZLNEWVIAGNAW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc2c(cc1C(=O)N)c(c[nH]2)CCN
CACTVS 3.385NCCc1c[nH]c2ccc(cc12)C(N)=O
FormulaC11 H13 N3 O
Name3-(2-azanylethyl)-1H-indole-5-carboxamide
ChEMBLCHEMBL18840
DrugBank
ZINCZINC000002539813
PDB chain7x5h Chain R Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7x5h Structural insights into the ligand binding and G i coupling of serotonin receptor 5-HT 5A .
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D121 C125 V194 S204 F301 F302 E305
Binding residue
(residue number reindexed from 1)		D84 C88 V157 S167 F222 F223 E226
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001586 Gi/o-coupled serotonin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0030594 neurotransmitter receptor activity
GO:0046872 metal ion binding
GO:0051378 serotonin binding
GO:0099589 serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0021766 hippocampus development
GO:0022900 electron transport chain
GO:0032355 response to estradiol
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042597 periplasmic space
GO:0043204 perikaryon
GO:0099634 postsynaptic specialization membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x5h, PDBe:7x5h, PDBj:7x5h
PDBsum7x5h
PubMed35610220
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P47898|5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (Gene Name=HTR5A)

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