Structure of PDB 7wvw Chain R Binding Site BS01

Receptor Information
>7wvw Chain R (length=299) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLA
LADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGF
IALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVT
IPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFLLPMSIVA
ICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWL
KEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wvw Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		L81 F110 Y175 T177 R201 R205 W254 F257 V284 F292
Binding residue
(residue number reindexed from 1)		L63 F92 Y157 T159 R183 R187 W236 F239 V266 F274
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding
GO:0004875 complement receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004982 N-formyl peptide receptor activity
GO:0005124 scavenger receptor binding
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0038023 signaling receptor activity
GO:0038024 cargo receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0001774 microglial cell activation
GO:0002430 complement receptor mediated signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0019722 calcium-mediated signaling
GO:0022900 electron transport chain
GO:0032930 positive regulation of superoxide anion generation
GO:0042742 defense response to bacterium
GO:0045089 positive regulation of innate immune response
GO:0048143 astrocyte activation
GO:0050728 negative regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050918 positive chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090026 positive regulation of monocyte chemotaxis
GO:1904646 cellular response to amyloid-beta
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035579 specific granule membrane
GO:0042597 periplasmic space
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wvw, PDBe:7wvw, PDBj:7wvw
PDBsum7wvw
PubMed35365641
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P25090|FPR2_HUMAN N-formyl peptide receptor 2 (Gene Name=FPR2)

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