Structure of PDB 7vvo Chain R Binding Site BS01

Receptor Information
>7vvo Chain R (length=302) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKEEQIFLLHRAQAQCEKRLVVAVPCPDYIYDFNHKGHAYRRCDRNGSWE
LVPGHNRTWANYSECVKFLRLGMIYTVGYSVSLASLTVAVLILAYFRRLH
CTRNYIHMHLFLSFMLRAVSIFVKDAGCRVAVTFFLYFLATNYYWILVEG
LYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANGNKKW
IIQVPILASIVLNFILFINIVRVLATKLRETDTRQQYRKLLKSTLVLMPL
FGVHYIVFMATPYTEVHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWS
RW
Ligand information
Receptor-Ligand Complex Structure
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PDB7vvo Endogenous ligand recognition and structural transition of a human PTH receptor.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		I237 F288 L289 L292 Q364 T427 E444
Binding residue
(residue number reindexed from 1)		I121 F135 L136 L139 Q203 T261 E269
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004991 parathyroid hormone receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vvo, PDBe:7vvo, PDBj:7vvo
PDBsum7vvo
PubMed35932760
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

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