Structure of PDB 7s0f Chain R Binding Site BS01

Receptor Information
>7s0f Chain R (length=272) Species: 9103 (Meleagris gallopavo) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLL
VVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAI
TSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCY
QDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIFR
EHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYA
NSAFNPIIYCRSPDFRKAFKRL
Ligand information
Ligand ID5FW
InChIInChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3/t11-/m0/s1
InChIKeyJWZZKOKVBUJMES-NSHDSACASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.6.1CC(C)NC[C@@H](c1ccc(c(c1)O)O)O
CACTVS 3.352CC(C)NC[C@H](O)c1ccc(O)c(O)c1
CACTVS 3.352CC(C)NC[CH](O)c1ccc(O)c(O)c1
OpenEye OEToolkits 1.6.1CC(C)NCC(c1ccc(c(c1)O)O)O
FormulaC11 H17 N O3
NameISOPRENALINE
ChEMBLCHEMBL1160723
DrugBank
ZINCZINC000000056652
PDB chain7s0f Chain R Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7s0f Structural basis and mechanism of activation of two different families of G proteins by the same GPCR.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		W117 D121 V125 F201 S211 F306 F307 N329
Binding residue
(residue number reindexed from 1)		W74 D78 V82 F158 S168 F222 F223 N245
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7s0f, PDBe:7s0f, PDBj:7s0f
PDBsum7s0f
PubMed34759376
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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