Structure of PDB 7r45 Chain R Binding Site BS01

Receptor Information
>7r45 Chain R (length=95) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVRTSPTGEKVTHTGQVYDDGDYRKVRFVGRQKEVNENFAIDLIAEQPVS
QVGSRVISCDGGGGALGHPRVYINLDKETKTGTCGYCGLQFRQQH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7r45 Chain R Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r45 Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C59 H68 C84 C87
Binding residue
(residue number reindexed from 1)		C59 H68 C84 C87
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Biological Process
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Cellular Component
External links
PDB RCSB:7r45, PDBe:7r45, PDBj:7r45
PDBsum7r45
PubMed36701435
UniProtP23934|NDUS6_BOVIN NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Gene Name=NDUFS6)

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