Structure of PDB 7o9m Chain R Binding Site BS01

Receptor Information
>7o9m Chain R (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRNRVTDRYFRIQEVLKHARHFRGRKNRCYRLAVRTVIRAFVKCTKARYL
KKKNMRTLWINRITAASQEHGLKYPALIGNLVKCQVELNRKVLADLAIYE
PKTFKSLAALASRRRHEGFAAALGDGKEPEGIFSRVVQYH
Ligand information
>7o9m Chain A (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaa
uagauauaguaccgcaagggaaagaugaaaaaaccaagcauaauauagca
aggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuu
gcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaaga
acagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuua
uagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaag
auagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccc
cuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuag
gaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccua
aaagcagccaccaauuaagaaagcguucaagcucaacacccacuaaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauacacugaacugacaauuaacagcccaauauc
uacaaucaaccaacaagucauuauuacccucacugucaacccaacacagg
caugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuu
accccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagag
gcaccgccugcccagugaucacuuguuccuuaaauagggaccuguaugaa
uggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaacacucaauugauccaauaacuugaccaacggaacaagu
uacccuagggauaacagcgcaauccuauucuagaguccauaucaacaaua
ggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcu
auuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuca
gaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuaguauuauacccacacccacccaagaacag
gguu
<<<.......<<<<..................................<.
.....>...............<<.....>>.............>>.>>..
...........<<....>>.................>>>...........
<<<.......>>>...<.<<......>>.>.<<<<<<.........<<<.
<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<
<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.
>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<.
...<<<<....>>>>.<<.<<<<<<<<<<.....<<..........>>..
...>>>>>>>>>>..>>..<<<<<<<<<<....(.>>>>>>>>>>...<<
<......>>>....<<<.<<<...<..............<....<<<...
......>>>....>.......<<<......>>>.................
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>>.......<<..<<<....>>><<<<..
<<<<........<<<<<..........>>>>>......<<<...<<<<..
.....................>>>>.......>>>.....<<......>>
.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......
<<<<<<..<<<.........>>>...<<<<<<.............>>>>>
>....<<<.....<<<<..>>>>.<<<<<<.....>>>>>>.........
.>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.........
..<<<<<........>>>>>.......<<..<<<.<<<....<<<<<.<<
<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.[.[.
>>>><<<<<.............>>>>>..<<.....<<<..<<<<.....
>>>>..>>>.....>>.........<<<....>>>............>>>
>..>>>>>>>..........<<<<<<<<<...<<.......>>...>>>>
>>>>>)....].].....<<<<<..<<<<<..<<.<<<<<<......>>>
>>>...>>.<<<<<.....>>>>>.....>>>>>......>>>>>.....
<<<<<<<....>>>.>>>>...>>>..>>>.>>.....<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>.................<<<<.......>
>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7o9m Structural basis for late maturation steps of the human mitoribosomal large subunit.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		L10 R11 N12 R13 V14 R17 R20 H30 F31 R32 R34 K35 R37 C38 Y39 R40 L41 V43 R44 R48 A49 K52 C53 A56 R57 Y58 K60 K61 K62 M64 R65 W68 I69 Y83 P84 N98 R99 K100 R124 F128
Binding residue
(residue number reindexed from 1)		L1 R2 N3 R4 V5 R8 R11 H21 F22 R23 R25 K26 R28 C29 Y30 R31 L32 V34 R35 R39 A40 K43 C44 A47 R48 Y49 K51 K52 K53 M55 R56 W59 I60 Y74 P75 N89 R90 K91 R115 F119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7o9m, PDBe:7o9m, PDBj:7o9m
PDBsum7o9m
PubMed34135318
UniProtQ9BYC9|RM20_HUMAN Large ribosomal subunit protein bL20m (Gene Name=MRPL20)

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