Structure of PDB 7dfl Chain R Binding Site BS01

Receptor Information
>7dfl Chain R (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVG
AVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYR
SVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRRE
DKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCLHMNRE
RKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYIN
STLNPLIYPLCNENFKKTFKRILHI
Ligand information
Ligand IDHSM
InChIInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKeyNTYJJOPFIAHURM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1c(nc[nH]1)CCN
CACTVS 3.341NCCc1c[nH]cn1
ACDLabs 10.04n1c(cnc1)CCN
FormulaC5 H9 N3
NameHISTAMINE
ChEMBLCHEMBL90
DrugBankDB05381
ZINCZINC000000388081
PDB chain7dfl Chain R Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7dfl Cryo-EM structure of the human histamine H 1 receptor/G q complex.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Y108 T112 N198 Y431 F432
Binding residue
(residue number reindexed from 1)		Y81 T85 N171 Y221 F222
Annotation score4
Binding affinityBindingDB: EC50=190nM,Ki=6000nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007613 memory
GO:0008542 visual learning
GO:0043114 regulation of vascular permeability
GO:0045907 positive regulation of vasoconstriction
GO:0048167 regulation of synaptic plasticity
GO:0071420 cellular response to histamine
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dfl, PDBe:7dfl, PDBj:7dfl
PDBsum7dfl
PubMed33828102
UniProtP35367|HRH1_HUMAN Histamine H1 receptor (Gene Name=HRH1)

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