Structure of PDB 7aue Chain R Binding Site BS01

Receptor Information
>7aue Chain R (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVA
DMLVSVSNGSETIVITLLNSFTVNIDNVIDSVICSSLLASICSLLSIAVD
RYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIIC
LITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGNMKGAITLTILIGVF
VVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYAL
RSQELRKTFKEII
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7aue Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		T101 I104 D122 I129 I185 S188 F284
Binding residue
(residue number reindexed from 1)		T62 I65 D76 I83 I139 S142 F230
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0031625 ubiquitin protein ligase binding
GO:0042562 hormone binding
GO:0042923 neuropeptide binding
Biological Process
GO:0002024 diet induced thermogenesis
GO:0006112 energy reserve metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
GO:0019222 regulation of metabolic process
GO:0030073 insulin secretion
GO:0032868 response to insulin
GO:0045780 positive regulation of bone resorption
GO:0060259 regulation of feeding behavior
GO:1903925 response to bisphenol A
GO:1903998 regulation of eating behavior
GO:1990680 response to melanocyte-stimulating hormone
GO:2000252 negative regulation of feeding behavior
GO:2000821 regulation of grooming behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aue, PDBe:7aue, PDBj:7aue
PDBsum7aue
PubMed33858992
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R)

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