Structure of PDB 7a18 Chain R Binding Site BS01

Receptor Information

>7a18 Chain R (length=110) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

PSAGSHHNDKLHFKKGDTVIVLSGKHKGQTGKVLLALPRDQKVVVEGVNV
ITKNVKPSMTNPQGGQEQRELALHASKVALVDPETGKATRVRKQIVDGKK
VRVAVASGKT

Ligand information

>7a18 Chain X (length=2699)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaac
cgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcugg
aaagcuacaccucagaaggugagaguccuguaggcgaacgagcccugagu
aggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaa
ggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggu
gaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuua
caagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaug
agccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcg
gagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacuc
gaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggagg
accgaaccggugccugcugaaacagucucggaugaguuguguuuaggagu
gaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauuga
gguacagccucggauguugaccauguccuguagagcacucacaaggcuaa
aaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcug
cgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcua
aggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagaca
gccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagc
ucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucu
accgaagcuauggauucaacucggaguugucugguaggggagcguucagu
ccgcggagaagccauaccggaaggagugguggagccgacugaagugcgga
ugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaagg
acaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaa
ggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcac
cgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcu
auggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuac
cggucugccucagacguaucgggagccgaaguuggaaacgcgacggugcc
aagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgac
acagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguua
aggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgc
ugcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacag
cacucugccaacacgaacaguggacguauagggugugacgccugcccggu
gccggaaggucaaguggagcggugcaagcugcgaaaugaagccccgguga
acggcggccuaagguagcgaaauuccuugucggguaaguuccgaccugca
cgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaau
ugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagacccc
guggagcuuuacuauagucuggcauugggauucggguuucuagaaacuug
gauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguu
ugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucac
cucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuu
gacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaac
cggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccg
gggauaacaggcugaucucccccgagaguccauaucggcggggagguuug
gcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaagg
guugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacguc
gugagacaguucggucucuauccgcuacgggcgcaggagaauugagggga
guugcuccuaguacgagaggaccggagugaacggaccgcuggucucccug
cugucguaccaacggcacaugcaggguagcuauguccggaacggauaacc
gcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacug
aagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgc
auagcaauguguucagcggacuggugcucaucagucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<......>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<....<
<<<<<<<....>>>>>>>>......<<<....<<..<<<...<<<<<...
...>>>>>((......<<<.....))>>>...>>>....>>..>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..
>>>......>>.>>>>>>.>>..............<<....>>....>>.
........<<<<....>>>>..................>>>>>>>>>>>.
......<<<<<<<<<<.......>>>>>>>>>>...<............>
.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>.
..<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.
<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......
>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<
.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<...
.>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<....
..>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<
<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<<<<<<........
<<<<<.<<.....<.........>.....>>..........<......>.
...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.
>>>...>>>>>>><..<<<<<...>>>>>..>....>>>>>><.<<<<<<
<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>....
.>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...
<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))
<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<.
..[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>
>>>>>.>>>>..>>>>>>>>>..........>>>>>...>>>...>>>>.
........>>>>...>>......>>>>>>>>>>>>>..>>.....<<...
...>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<....<....>.....>>>>><<<<<<<<
.>>>>>>>>............<<<<<<<<<..<<...........>>..<
<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<
<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..
>>>>>...........<...........<<<<<<.....>>>>>>.....
>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....
>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<
<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<<......>>>..>
>>>>>>...<<<<<<.......>>.>>>>....>>>>>.>>>..>>>>>.
.<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>.
..<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......
<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>
>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>
>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>
>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<.
.<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<
<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<
<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.
.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<
<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a18 Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): P4 H9 H10 N11 K13 H15 K17 K18 S26 G27 A39 P41 K45 I54 K56 N57 V58 K59 Q69 L74 H77 V94
• Binding residue (residue number reindexed from 1): P1 H6 H7 N8 K10 H12 K14 K15 S23 G24 A36 P38 K42 I51 K53 N54 V55 K56 Q66 L71 H74 V91

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7a18, PDBe:7a18, PDBj:7a18
• PDBsum: 7a18
• PubMed: 34417608
• UniProt: Q9RXJ1|RL24_DEIRA Large ribosomal subunit protein uL24 (Gene Name=rplX)