Structure of PDB 6wzg Chain R Binding Site BS01

Receptor Information

>6wzg Chain R (length=379) Species: 9606 (Homo sapiens)

RLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSS
VPGRMVEVECPRFLRMLTSRNGSLFRNCTQDGWSETFPRPNLACGVNVND
SSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHM
HLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLVMVLFQYCIMAN
YSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHF
LEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQET
RGNEVSHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSF
QGLVVAVLYCFLNGEVQLEVQKKWQQWHL

Ligand information

>6wzg Chain P (length=27) Species: 9606 (Homo sapiens)

HSDGTFTSELSRLREGARLQRLLQGLV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wzg Structure and dynamics of the active Gs-coupled human secretin receptor.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): R30 L31 V125 H136 L139 K143 Y146 Y150 N192 K195 F200 S202 D203 F222 Q223 I226 Y230 D287 I288 N289 I298 M366 L370 E373 L374
• Binding residue (residue number reindexed from 1): R1 L2 V96 H107 L110 K114 Y117 Y121 N163 K166 F171 S173 D174 F193 Q194 I197 Y201 D258 I259 N260 I269 M337 L341 E344 L345

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity
• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007166 cell surface receptor signaling pathway
• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6wzg, PDBe:6wzg, PDBj:6wzg
• PDBsum: 6wzg
• PubMed: 32811827
• UniProt: P47872|SCTR_HUMAN Secretin receptor (Gene Name=SCTR)