Structure of PDB 6wkr Chain R Binding Site BS01

Receptor Information
>6wkr Chain R (length=108) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAE
ILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNI
QSVLLPKC
Ligand information
>6wkr Chain H (length=314) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caggatgtatatatctgagacgtgcctggagactagggagtaatcccctt
ggcggtttaaacgcgggggacagcgcgtacgtgcgttttagcggtgctag
agctgtctacgaccaattgagcggcctgggcaccgggattctccagccgc
cggcagcgctgccggcggctggagaatcccggtgccgaggccgctcaatt
ggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgtccccc
gcgtttaaaccgccaaggggattactccctagtctccaggcacgtctcag
atatatacatcctg
Receptor-Ligand Complex Structure
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PDB6wkr JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		A14 K15 R17 R20 R32 R42 V43 A45 K75 T76 R77
Binding residue
(residue number reindexed from 1)		A3 K4 R6 R9 R21 R31 V32 A34 K64 T65 R66
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6wkr, PDBe:6wkr, PDBj:6wkr
PDBsum6wkr
PubMed33479123
UniProtP06897|H2A1_XENLA Histone H2A type 1

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