Structure of PDB 6w6p Chain R Binding Site BS01

Receptor Information
>6w6p Chain R (length=118) Species: 474186 (Enterococcus faecalis OG1RF) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARVKGGTVTRKRRKKVLKLAKGYYGSKHTLFKSAKEQVMNSYYYAFRDRR
QKKRDFRKLWIARINAAARMNGLSYSKLMHGLKLAEIDINRKMLADLAVN
DAAAFTALAEQAKDALSK
Ligand information
>6w6p Chain A (length=2739) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguag
gacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauucc
gcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggag
gauccugaguacggcggaacacgagaaauuccgucggaauccgcggggac
caucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccg
ugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaa
accgugugccuacaacaagucaaagcucguuaaugagugauggcgugccu
uuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaag
agacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguag
ucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgg
uaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaug
agguguggguagcggagaaauuccaaacgaacuuggagauagcugguucu
cuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguag
agcacuguuuggacuaguucagauaaacuccgaaugccauucauuuauau
ccgggagucagacugcgagugauaagauccguagucgaaagggaaacagc
ccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugu
gggguugcacagacaacuaucgagugacccugcgccgaaaauguaccggg
gcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguag
gagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgc
uuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccug
uccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguua
gucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguug
auauuccuguaccaguuguuuguuugagcaauggagggacgcaguaggcu
aaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugagua
gaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaaua
guagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaa
acaacugcccguaccguaaaccgacacagguagucgaggagaguauccua
aggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaa
cuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaa
gcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaagua
uaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcu
ucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacga
aaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuu
aguaccugugaagaugcagguuacccgcgacaggacggaaagaccccaug
gagcuuuacuguaguuugauauugaguguuuaacccucuaacccgcacca
cuaaucguggugggagacagugucagaugggcaguuugacuggggcgguc
gccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguugg
aaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccua
caagucgagcagggacgaaagucgggcuuagugauccggugguuccgcau
ggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuu
aucucccccaagaguccacaucgacggggagguuuggcaccucgaugucg
gcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgc
ccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucgg
ucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguac
gagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagg
gcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaa
gugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaag
accccugagagaugaucagguagauagguuggaaguggaaggcuagugau
aguuggagcggaccaauacuaaucggucgaggacuuaac
<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<
<<<<<<...<.<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>
((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>.>>>>
..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<
<<<>>>>>..)))......]].>>>>>>>.]]...............<<.
...>>....]].........<<<<....>>>>..................
>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<
........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<....
.>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>
>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<.
.....>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>...
.>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<
<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<<.....<
<<...<<<<<<<<....>>>>>>>>..>>.>.....>>>>.>>>>>..>>
>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>
>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<
<<<<<<<........<...>....>>>>>>>>>.>>...........)))
.....>>>>>>.>>>...>>>>>>><<<<<<<......>>>>>>>....>
>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>
>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>
>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<...
.....>>>>>))<<<<<<<.........<...<<<<....<<<<..<<<.
.<<<<<...........{...........<<..<<<<<..<<<<.<<<<<
<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<......
...>>....>>>>>...>>>...>>>>.........>>>>..>.......
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.
.>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....
<<..>>.....>>>>><<<<<<....>>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<<....>>>......
.>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<.
...>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<<.....>>>>>>.....>..
..>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<<<<<<<.<<<.<<<.>>>.>>>....<<.<<<<<
<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>>
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<....
...>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<...
...>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>
>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.
<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<
<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>
>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>..
..]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<......
.........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>
>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>
>>>>...>>>>.>>>>.......>>>>>>>..<<<......>>>.....<
<<<<<<<<.......>>>>>....<<<<<<<<..<<.....<<<<....>
>>>....>>...>>>>>.>>>...>>>>....>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w6p Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		A2 R3 V4 T8 R11 R13 R14 K15 K22 G23 Y24 Y25 G26 S27 H29 K33 K36 E37 Q38 S42 Y45 R48 D49 R50 R51 K54 R55 F57 R58 K59 N66 R70 Y76 S77 N91 R92 K93
Binding residue
(residue number reindexed from 1)		A1 R2 V3 T7 R10 R12 R13 K14 K21 G22 Y23 Y24 G25 S26 H28 K32 K35 E36 Q37 S41 Y44 R47 D48 R49 R50 K53 R54 F56 R57 K58 N65 R69 Y75 S76 N90 R91 K92
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6w6p, PDBe:6w6p, PDBj:6w6p
PDBsum6w6p
PubMed33004869
UniProtA0A1B4XM76

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