Structure of PDB 6vsu Chain R Binding Site BS01

Receptor Information
>6vsu Chain R (length=316) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSIEKGQNRVIDASLTLIRERAKLKGELVRLLGGAKASTSLLGVPLGHNS
SFLQGPAFAPPRIREAIWCGSTNSATEEGKELKDPRVLTDVGDVPVQEIR
DCGVDDDRLMNVISESVKLVMEEEPLRPLVLGGDHSISYPVVRAVSEKLG
GPVDILHLDAHPDIYDCFEGNKYSHASSFARIMEGGYARRLLQVGIRSIN
QEGREQGKRFGVEQYEMRTFSKDRPMLENLKLGEGVKGVYISIDVDCLDP
AFAPGVSHIEPGGLSFRDVLNILHNLQADVVGADVVEFNPQRDTVDGMTA
MVAAKLVRELAAKISK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6vsu Chain R Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vsu The Neighboring Subunit Is Engaged to Stabilize the Substrate in the Active Site of Plant Arginases.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		D185 H187 D270 D272
Binding residue
(residue number reindexed from 1)		D159 H161 D244 D246
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.3.1: arginase.
3.5.3.11: agmatinase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004053 arginase activity
GO:0008783 agmatinase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0046872 metal ion binding
GO:0050897 cobalt ion binding
Biological Process
GO:0000050 urea cycle
GO:0006525 arginine metabolic process
GO:0006527 arginine catabolic process
GO:0009446 putrescine biosynthetic process
GO:0033388 putrescine biosynthetic process from arginine
GO:0033389 putrescine biosynthetic process from arginine, using agmatinase
GO:0034214 protein hexamerization
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vsu, PDBe:6vsu, PDBj:6vsu
PDBsum6vsu
PubMed32754173
UniProtP46637|ARGI1_ARATH Arginase 1, mitochondrial (Gene Name=ARGAH1)

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