Structure of PDB 6v3d Chain R Binding Site BS01

Receptor Information

>6v3d Chain R (length=109) Species: 1310637 (Acinetobacter sp. 809848)

MEVTAKLRGAAISAQKARLVADLIRGKSVAHALNILNFSNKKAAVLVKKA
LESAIANAEHNNSLDVDDLKVSTIYVDEGMSLKRIMPRAKGRADRITKRT
CHITVKVGV

Ligand information

>6v3d Chain AN1 (length=2892)

agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgau
gaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuu
ugauccggagaugucugaaugggggaacccaccuacuuuaagguagguau
ugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacau
cucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcg
agcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcuc
ugggaagugcgaacguagagggugauauucccguacacgaaagggcacac
auaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggg
gggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccag
uaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagau
ccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacug
cguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaa
ccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguug
cuggguauagacccgaaaccaggcgaucuauccaugagcagguugaaggu
uggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggg
gaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugg
uucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggg
uagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugca
aacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaa
cguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaa
aucauaguuaagugggaaacgaugugggaaggcauagacagcuaggaggu
uggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucg
agucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcu
gcggauguauacuuuguauacgugguaggggagcguucuguaagccgaug
aagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacg
ugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaagggu
uccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggc
cgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucugugu
aaugcgaugagaggacggagaaggcuaaaucagccuggcguugguugucc
aggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaug
cugagaucugauagcaagcuguacuuguacagcgaagugguugaugccau
gcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaa
accgacacagguggucaggucgaguagaccaaggcgcuugagagaacucu
gcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcu
guuguuggugauggaacucgcuuccugagcugacgacagccgcagaaacc
aggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaag
uggacguauagggugugaugccugcccggugcuggaagguuaauugaugg
gguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccgu
aacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgac
cugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagu
gaaaucgaaaucgcugugaagaugcaguguacccgcggcuagacggaaag
accccgugaaccuuuacugcagcuugacacugaacuuugaccuuacuugu
guaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagcc
guccuugaaauaccacccugguaauguugagguucuaacucugucccgug
auccgggacgaggaccgugucugguggguaguuugacuggggcggucucc
uccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaa
ucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaa
gucgagcagguacgaaaguaggucuuagugauccggugguucuguaugga
agggccaucgcucaacggauaaaagguacucuggggauaacaggcugaua
ccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcu
caucucauccuggggcugaagcaggucccaaggguauggcuguucgccau
uuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucc
cuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgag
aggaccagaguggacgaaccucugguguaccgguugugacgccagucgca
ucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcg
ggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaag
agccguucgagacuaggacguugauagguuggauguggaagcauagugau
augugaagcugaccaauacuaauugcucgugaggcuugacua

<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>..
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>
>......>>>>>.>...[.....<<....>>...<<<<<.....<<....
.>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<
......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>
>>>>>...........<<<<<<<<.........>>>>>>>>......<<<
<<..<<<<>>>>>..>>>....].]].>>>>>>>.]].............
..<<....>>....]].........<<<<.....>>>>............
.}....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>
>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...
<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>
>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<
<<<......>>>>>>...>.>>>...<<<.<<<.<........>.>>>>>
>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>
..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<...
..<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>
..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<.....
.>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...
..<<<<<<...........<<.<<<<<<..<.........<<<<...<..
...<.........>......>........<<........>>...>>>>..
...>..>>>>>>>>...........)))......>>>>>>.>>>...>>>
>>>><<<<<<.......>>>>>>....>>>>>><.<<<<<...<<<....
..<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><
......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<..
.<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<
<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<
<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>
>>>>....<<<<...<<<<<.<<<<<<.<<.....>>>>>>>>....>>>
>>...>>>>...........<......>.........>>>>>...>>>..
.>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>....
.<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<
<<<<.<<...............<<<<<.....<..>......>>>>><<<
<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>..........
..<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>
>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<
<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.
........>>>>>........<...........<<<<<<.....>>>>>>
.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>
.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[....
..<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<...
.........<<.................<<........>>..........
..............>>...>>>>>.>>>>>>>>>>...<<<.<<<<<<..
...>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......
>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>.
.))>>>>>>>.............>>>>..]]>>>>.......<<<<...<
<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.
<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]
]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<..........
.......>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>
..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>
>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<
<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>
>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6v3d Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development.
• Resolution: 2.95 Å
• Binding residue (original residue number in PDB): K6 R8 S13 Q15 K16 R18 K41 K42 K49 A56 N57 H60 N61 D77 E78 M80 K83 R84 P87 R88 A89 K90 G91 R92 A93 D94 I96 T97 K98
• Binding residue (residue number reindexed from 1): K6 R8 S13 Q15 K16 R18 K41 K42 K49 A56 N57 H60 N61 D77 E78 M80 K83 R84 P87 R88 A89 K90 G91 R92 A93 D94 I96 T97 K98

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6v3d, PDBe:6v3d, PDBj:6v3d
• PDBsum: 6v3d
• PubMed: 31964740
• UniProt: A0A009QSN8