Structure of PDB 6tps Chain R Binding Site BS01

Receptor Information

>6tps Chain R (length=325) Species: 559292 (Saccharomyces cerevisiae S288C)

MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKSDEERKFWKKYEKP
EKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHCTKEN
KLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYK
IFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRF
VQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMLIDKISEWVL
TPPFMEDAEVWFIYASCHLLKADTLSRQFVDIKINQVIKHIHYVRTFLKI
CLDKGGFAVPSRLIENQLKSFESRL

Ligand information

>6tps Chain S (length=27)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 6tps Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting.
• Resolution: 3.54 Å
• Binding residue (original residue number in PDB): R11 T181 N287
• Binding residue (residue number reindexed from 1): R11 T97 N203

Gene Ontology

Molecular Function

• GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
• GO:0001181 RNA polymerase I general transcription initiation factor activity
• GO:0005515 protein binding
• GO:0017025 TBP-class protein binding

Biological Process

• GO:0001188 RNA polymerase I preinitiation complex assembly
• GO:0006361 transcription initiation at RNA polymerase I promoter
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0070860 RNA polymerase I core factor complex

External links

• PDB: RCSB:6tps, PDBe:6tps, PDBj:6tps
• PDBsum: 6tps
• PubMed: 32139698
• UniProt: Q04712|RRN11_YEAST RNA polymerase I-specific transcription initiation factor RRN11 (Gene Name=RRN11)