Structure of PDB 6rwe Chain R Binding Site BS01

Receptor Information

>6rwe Chain R (length=330) Species: 559292 (Saccharomyces cerevisiae S288C)

MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSSDEERKFWKKYE
KPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHCTK
ENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLA
YKIFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKS
RFVQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMLIDKISEW
VLTPPFMEDAEVWFIYASCHLLKADTLSRQFVNRDIKINQVIKHIHYVRT
FLKICLDKGGFAVPSRLIENQLKSFESRLY

Ligand information

>6rwe Chain T (length=50)

actgctttcgcatgaacctcccaactacttttcctcacacttgtactcca

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rwe Molecular insight into RNA polymerase I promoter recognition and promoter melting.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): K18 N289 Y290 R291
• Binding residue (residue number reindexed from 1): K18 N207 Y208 R209

Gene Ontology

Molecular Function

• GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
• GO:0001181 RNA polymerase I general transcription initiation factor activity
• GO:0005515 protein binding
• GO:0017025 TBP-class protein binding

Biological Process

• GO:0001188 RNA polymerase I preinitiation complex assembly
• GO:0006361 transcription initiation at RNA polymerase I promoter
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0070860 RNA polymerase I core factor complex

External links

• PDB: RCSB:6rwe, PDBe:6rwe, PDBj:6rwe
• PDBsum: 6rwe
• PubMed: 31804486
• UniProt: Q04712|RRN11_YEAST RNA polymerase I-specific transcription initiation factor RRN11 (Gene Name=RRN11)