Structure of PDB 6r7n Chain R Binding Site BS01

Receptor Information
>6r7n Chain R (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSE
ECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6r7n Chain R Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r7n Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Resolution6.5 Å
Binding residue
(original residue number in PDB)		D51 L52
Binding residue
(residue number reindexed from 1)		D35 L36
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
2.3.2.32: cullin-RING-type E3 NEDD8 transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6r7n, PDBe:6r7n, PDBj:6r7n
PDBsum6r7n
PubMed31444342
UniProtP62877|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)

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