Structure of PDB 6g4w Chain R Binding Site BS01

Receptor Information

>6g4w Chain R (length=81) Species: 9606 (Homo sapiens)

GRVRTKTVKKAARVIIEKYYTRLNDFHTNKRVCEEIIIPSKKLRNKIAGY
VTHLMKRIQRGPVRGISIKLQEEERERRDNY

Ligand information

>6g4w Chain 2 (length=1563)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggcagcuccaauagcgu
auauuaaaguugcugcaguuaaaaagcucguaguuggaucucucucggcc
gaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggau
accgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuu
ucggaacugaggccaugauuaagagggacggccgggggcauucguauugc
gccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaa
gcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucg
aagacgauaccgucguaguuccgaccauaaacgaugccgaccggcgaugc
ggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaaguc
uuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauug
acggaagggcaccaccaggaguggagccugcggcuuaauuugacucaaca
cgggaaaccucacccggcccggacacggacaggauugacagauugauagc
ucuuucucgauuccguggguggugcauggccguuccugguuaauuccgau
gacucuggcaugcuauucuuagagggacaaguggcguucagccacccgag
auugagcuaacaggucugugugcccuguccggggcugcacgcgcgcuaca
cugacuggcucagcguguccuacgccggcaggcgcggguaacccguugaa
ccccauucgugauggggaucggggauugcaauuauuccccaugaacgagg
aauucccaguaagugcgggucauaagcuugcguugauuaagucccugccc
uuugcaccgcgucgcuacuaccgauuggaugguuuagugaggcccucgga
ucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuu
gacuaucuagaggaaguaaaagucggguuuccguaggugaaccugcggaa
ggaucauuaacgg

...<<<<<.[.(((.>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>....>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>..
.>>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<.>>>.>>>>>..>>>>
>>.>>>.........<.........<.<<...<<<.<<...<<.<<<<>>
>>>>...<<<<<<.<.......<<...<.......>.<<<<.>>>>...>
>......>.>>>..>>>........<.<<.<<<<<<<.............
..>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<
<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....
>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<.
..<<<<....>>>>...>>>>>>>>..........<<<.<<.<<<..<.<
<<<<<.<<<........>>>>>>>>>.>..>>>...<<....>>...>>.
....>>>...>.<<<......<<<<....>>>>....>>>...))).]..
.<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<<.......<........
>...........<<<<<......<<<<<<.......<..<<<........
>>>..>.....>>>>>>...<<<<<<<<<<<<<...<<<......>>>..
..<<<...<...<<......>>..>.....<<<<<.....>>>>>.....
...>>>...>>.>>>>.>>>>>>>....>>>>>...>>.>>>>.>>>.>.
..<<.<<<........<.<<<.<<<<....>>>>.>>>....>.......
..>>>.>>......<.....<<<<<..........>>>>>.....>....
.>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>
>>>>.<<<.<<....<<<<.<<....<<<<<<<<.<<<..<<<<.<<...
<<<<<<<<<<<<<<<<>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.
>>>>>>>>...>>.>>>>.....>>>>><<<<<<<<<....>>>>>>>>>
.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g4w Visualizing late states of human 40S ribosomal subunit maturation.
• Resolution: 4.5 Å
• Binding residue (original residue number in PDB): K45 N48 K49 G52 T55
• Binding residue (residue number reindexed from 1): K42 N45 K46 G49 T52

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0006413 translational initiation
• GO:0034101 erythrocyte homeostasis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6g4w, PDBe:6g4w, PDBj:6g4w
• PDBsum: 6g4w
• PubMed: 29875412
• UniProt: P08708|RS17_HUMAN Small ribosomal subunit protein eS17 (Gene Name=RPS17)