Structure of PDB 6epf Chain R Binding Site BS01

Receptor Information
>6epf Chain R (length=389) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDTAVREELMAAVRENNM
APYYEALCKSLDWQMDMDLLSKMKKANEEELKRLDEELEDAEKNLGESEI
RDAMMAKAEYLCQIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLF
YMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAEL
FLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVL
HSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKV
NEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM
Ligand information
>6epf Chain Y (length=24) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NVEDDFSNQLRAELEKHGYKMETS
Receptor-Ligand Complex Structure
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PDB6epf In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Resolution11.8 Å
Binding residue
(original residue number in PDB)		F272 Q273 A276 E279 Q280 Y292 R293 V296 R297 R300 G317 Y318 E321 G324 V325 V327 F329 E333
Binding residue
(residue number reindexed from 1)		F272 Q273 A276 E279 Q280 Y292 R293 V296 R297 R300 G317 Y318 E321 G324 V325 V327 F329 E333
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005838 proteasome regulatory particle
GO:0022624 proteasome accessory complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6epf, PDBe:6epf, PDBj:6epf
PDBsum6epf
PubMed29398115
UniProtQ6PCT9

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