Structure of PDB 6epe Chain R Binding Site BS01

Receptor Information
>6epe Chain R (length=389) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDTAVREELMAAVRENNM
APYYEALCKSLDWQMDMDLLSKMKKANEEELKRLDEELEDAEKNLGESEI
RDAMMAKAEYLCQIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLF
YMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAEL
FLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVL
HSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKV
NEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM
Ligand information
>6epe Chain Y (length=24) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NVEDDFSNQLRAELEKHGYKMETS
Receptor-Ligand Complex Structure
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PDB6epe In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Resolution12.8 Å
Binding residue
(original residue number in PDB)		N14 D16 E47 S269 E279 K284 Y292 V296 R297 G317 A320 E321 G324 V325 G326 F329 Q332 E333 R336
Binding residue
(residue number reindexed from 1)		N14 D16 E47 S269 E279 K284 Y292 V296 R297 G317 A320 E321 G324 V325 G326 F329 Q332 E333 R336
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005838 proteasome regulatory particle
GO:0022624 proteasome accessory complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6epe, PDBe:6epe, PDBj:6epe
PDBsum6epe
PubMed29398115
UniProtQ6PCT9

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