Structure of PDB 5wvi Chain R Binding Site BS01

Receptor Information

>5wvi Chain R (length=400) Species: 559292 (Saccharomyces cerevisiae S288C)

NYEVSEKAFLLTQSKVSIEQRKEAAEFVLAKIKEEEMAPYYKYLCEEYLV
NNGQSDLEHDEKSDSLNEWIKFDQELYNELCKKNESKIKELNEKIQKLEE
DDEGELEQAQAWINLGEYYAQIGDKDNAEKTLGKSLSKAISTGAKIDVML
TIARLGFFYNDQLYVKEKLEAVNSMIEKGGDWERRNRYKTYYGIHCLAVR
NFKEAAKLLVDSLATFTSIELTSYESIATYASVTGLFTLERTDLKSKVID
SPELLSLISTTAALQSISSLTISLYASDYASYFPYLLETYANVLIPCKYL
NRHADFFVREMRRKVYAQLLESYKTLSLKSMASAFGVSVAFLDNDLGKFI
PNKQLNCVIDRVNGIVETNRPDNKNAQYHLLVKQGDGLLTKLQKYGAAVR

Ligand information

>5wvi Chain Y (length=27) Species: 559292 (Saccharomyces cerevisiae S288C)

ENWDDVEVDDDFTNELKAELDRYKREN

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5wvi High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx
• Resolution: 6.3 Å
• Binding residue (original residue number in PDB): R222 F305 L308 L309 H325 D327 F328 R331 S355 G358 V359 S360 F363 N374
• Binding residue (residue number reindexed from 1): R200 F283 L286 L287 H303 D305 F306 R309 S333 G336 V337 S338 F341 N352

Gene Ontology

Molecular Function

• GO:0005198 structural molecule activity
• GO:0005515 protein binding

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005838 proteasome regulatory particle
• GO:0008541 proteasome regulatory particle, lid subcomplex

External links

• PDB: RCSB:5wvi, PDBe:5wvi, PDBj:5wvi
• PDBsum: 5wvi
• PubMed: 28106073
• UniProt: Q06103|RPN7_YEAST 26S proteasome regulatory subunit RPN7 (Gene Name=RPN7)