Structure of PDB 5hyn Chain R Binding Site BS01
Receptor Information
>5hyn Chain R (length=365) Species:
9606
(Homo sapiens) [
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KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCEN
AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKM
LALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILI
AVCDDASIWRWDRLR
Ligand information
>5hyn Chain U (length=10) Species:
9606
(Homo sapiens) [
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LQAQRKFAQS
Receptor-Ligand Complex Structure
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PDB
5hyn
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Resolution
2.95 Å
Binding residue
(original residue number in PDB)
F97 Y148 N307 Y308 C324 D362 I363 W364 Y365 R414
Binding residue
(residue number reindexed from 1)
F21 Y72 N231 Y232 C248 D286 I287 W288 Y289 R338
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5hyn
,
PDBe:5hyn
,
PDBj:5hyn
PDBsum
5hyn
PubMed
27121947
UniProt
O75530
|EED_HUMAN Polycomb protein EED (Gene Name=EED)
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