Structure of PDB 3d48 Chain R Binding Site BS01

Receptor Information
>3d48 Chain R (length=195) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHEC
PDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIV
QPDPPLELAVEVKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE
IHFAGQQTEFKILSPGQKYLVQVRCKPDHGYWSAWSPATFIQIPS
Ligand information
Ligand IDCO3
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)([O-])[O-]
ACDLabs 10.04
CACTVS 3.341		[O-]C([O-])=O
FormulaC O3
NameCARBONATE ION
ChEMBL
DrugBankDB14531
ZINC
PDB chain3d48 Chain R Residue 211 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3d48 Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y190 W191
Binding residue
(residue number reindexed from 1)		Y181 W182
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004896 cytokine receptor activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3d48, PDBe:3d48, PDBj:3d48
PDBsum3d48
PubMed18467331
UniProtP16471|PRLR_HUMAN Prolactin receptor (Gene Name=PRLR)

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