Structure of PDB 2pmz Chain R Binding Site BS01

Receptor Information
>2pmz Chain R (length=1090) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTIDERWRVIEAYFKSKGLVRQHLDSYNDFVRNKLQEIIDEQGEIPTEIP
GLKVRLGKIRIGKPRVRESDRGEREISPMEARLRNLTYAAPLWLTMIPVE
NNIEAEPEEVYIGDLPIMLKSAIDPISQYTLDKLIEIGEDPKDPGGYFIV
NGSERVIVTQEDLAPNRVLVDTGKTGSNITHTAKIISSTAGYRVPVTIER
LKDGTFHVSFPAVPGKIPFVILMRALGILTDRDIVYAVSLDPEVQNELFP
SLEQASSIANVDDALDFIGSRVAIGQKRENRIEKAQQIIDKYFLPHLGTS
AEDRKKKAYYLAYAISKVIELYLGRREPDDKDHYANKRLRLAGDLFASLF
RVAFKAFVKDLTYQLEKSKVRGRKLALKALVRPDIVTERIRHALATGNWV
GGRTGVSQLLDRTNWLSMLSHLRRVISSLARGQPNFEARDLHGTQWGRMC
PFETPEGPNSGLVKNLALMAQIAVGINERIVEKTLYEMGVVPVEEVILKW
SKVILNGRLIGYYQDGGELANKIRERRRKGEISDEVNVGHIVTDFINEVH
VNCDSGRVRRPLIIVSNGNPLVTIEDIEKLESGAITFDDLVRQGKIEYLD
AEEEENAYVALEPNDLTPDHTHLEIWSPAILGITASIIPYPEHNQSPRNT
YQSAMAKQALGLYAANYQLRTDTRAHLLHYPQRPLVQTRALDIIGYTNRP
AGNNAILAVMSFTGYNMEDSIIMNRSSVERGMYRSTFFRLYSTEEVKYPG
GQEDKIVMPEAGVRGYKGKEYYRLLEDNGVVSPEVEVKGGDVLIGKVSPP
RAKRDTSIVTRHGEMGIVDLVLITETAEGNKLVKVRVRDLRIPTIGDKFA
SRHGQKGVIGMLIPQVDMPYTVKGVVPDIILNPHALPSRMTLGQIMEGIA
GKYAALSGNIVDATPFYKTPIEQLQNEILRYGYLPDATEVVYDGRTGQKI
KSRIYFGVVYYQKLHHMVADKLHARARGPVQILTRQPTEGRAREGGLRFG
EMERDCLIGFGTAMLLKDRLLDNSDRTMIYVCDQCGYIGWYDKNKNKYVC
PIHGDKSNLFPVTVSYAFKLLIQELMSMIISPRLVLEDKV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2pmz Chain R Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2pmz The X-ray crystal structure of RNA polymerase from Archaea
Resolution3.4 Å
Binding residue
(original residue number in PDB)
C1061 I1081
Binding residue
(residue number reindexed from 1)
C1032 I1052
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:2pmz, PDBe:2pmz, PDBj:2pmz
PDBsum2pmz
PubMed18235446
UniProtQ980R1|RPO2_SACS2 DNA-directed RNA polymerase subunit Rpo2 (Gene Name=rpo2)

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