Structure of PDB 8iuj Chain QD Binding Site BS01

Receptor Information
>8iuj Chain QD (length=241) Species: 3039 (Euglena gracilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDSHPPALPWPHFQWFQGLDWRSVRRGKEVYEQVFAPCHSLSFIKYRHFE
AFMSKEEVKNMAASFEVDDDPDEKGEARKRPGKRFDTVVQPYKNEQEARY
ANNGALPPDLSVITNARHGGVDYIYALLTGYGRPVPGGVQLSTTQWYNPY
FHGGIIGMPPPLTDDMIEYEDGTPASVPQMAKDVTCFLEWCSNPWWDERK
LLGYKTIATLAVIAVSSGYYNRFLSGLWRSRRLAFRPFNYS
Ligand information
Ligand IDHEC
InChIInChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,9-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;+4/b21-7?,22-8?,26-13-,29-14-,30-15-,31-16-;
InChIKeyHXQIYSLZKNYNMH-LJNAALQVSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)CCC1=C(C2=CC6=C(C(=C/C)\C5=CC4=C(C(\C3=Cc7c(c(c8C=C1N2[Fe](N34)(N56)n78)CCC(=O)O)C)=C/C)C)C)C
OpenEye OEToolkits 1.5.0CC=C1C(=C2C=C3C(=CC)C(=C4N3[Fe]56N2C1=Cc7n5c(c(c7C)CCC(=O)O)C=C8N6C(=C4)C(=C8CCC(=O)O)C)C)C
CACTVS 3.341C\C=C1/C(=C2C=C3N4C(=Cc5n6c(C=C7N8C(=C(C)\C7=C/C)C=C1N2[Fe@@]468)c(C)c5CCC(O)=O)C(=C3C)CCC(O)=O)C
CACTVS 3.341CC=C1C(=C2C=C3N4C(=Cc5n6c(C=C7N8C(=C(C)C7=CC)C=C1N2[Fe]468)c(C)c5CCC(O)=O)C(=C3C)CCC(O)=O)C
FormulaC34 H34 Fe N4 O4
NameHEME C
ChEMBL
DrugBank
ZINC
PDB chain8iuj Chain QD Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8iuj Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		F37 C40 H41 N104 P109 R119 Y125 L129 F153 M160 P163
Binding residue
(residue number reindexed from 1)		F35 C38 H39 N102 P107 R117 Y123 L127 F151 M158 P161
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.8: quinol--cytochrome-c reductase.
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuj, PDBe:8iuj, PDBj:8iuj
PDBsum8iuj
PubMed38388527
UniProtP20114|CY1_EUGGR Cytochrome c1, heme protein

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