Structure of PDB 6gzx Chain Q4 Binding Site BS01

Receptor Information
>6gzx Chain Q4 (length=100) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKY
KLGDVVEIIESRPISKRKRFRVLRLVESGRMDLVEKYLIRRQNYESLSKR
Ligand information
>6gzx Chain A4 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<......<<.
......<<<..<<...........................>>>>>.....
.<<.......<<<<<<<...<<...<<..<....<<<.......<<<...
...>>>........>>>.....<<<<..<<........>>..>>>>...<
<.......>>...>..>>..>>.>>>>>>><<<..........<<<<<<<
.......>>>>>>>..........>>>..<<<<<<<<....>>>...>>>
>>.>>..<.<<............>.>>..<<<<<..>>>>>.......>>
......<<.<<<.....<<......>>...>>>>>.>.>>>>>>..<<<<
......<.<<.....>>>.....>>>>....<<<<<........<<<...
...>.>>..........>>>>>......<<<<..(....<<<<<......
...)..........>>>>>.>>>>..>>>>>>>>>...........<<((
.....<<<<...<<<.<<<<<..<<<<<<<<.........<<<<<<....
.>>>>>>.......>>>>>..>>>.>>>>>..........<...<<<<<<
<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>........
...<......>.>>>>>>>..>...........>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<.<<<<...>>>>.>>>>>...<<..))>>.....>>>>
>>.>>..........<<<<......>>>>.........))).].<.<..<
<<<<<<.....<<<<....<<<<<<<........<<........>>....
.......<<<............<......<.<............>>....
..................>........<<...<<<<.<..<.....<<<<
.<<<....>>>..<<<<......>>>>...>>>>........<<..<<.<
<....<....<.......>..>.....>>.>>..................
..........>>.......>...>.>...>>>.>>.........>>>...
....>>>>>>>......<<<.........<<...<<...<<.......>>
..>>.....>>.........>>>...........<<<<<<<........>
>>>>>>...........>>>>......<<<<<<..........>>>>>>.
...........>>>>>>>.>..>........<<...<<<<.<<<..<<.<
<<<..<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>..>>>
>.>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>
>.....
Receptor-Ligand Complex Structure
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PDB6gzx Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.57 Å
Binding residue
(original residue number in PDB)		P2 K3 K4 S12 D13 K14 M15 K17 T18 K34 K37 R38 Y42 E61 S62 R63 P64 I65 S66 K67 R68 K69 R70 R72 R81 K87 R91 R92 N94 Y95 E96 L98 S99 K100 R101
Binding residue
(residue number reindexed from 1)		P1 K2 K3 S11 D12 K13 M14 K16 T17 K33 K36 R37 Y41 E60 S61 R62 P63 I64 S65 K66 R67 K68 R69 R71 R80 K86 R90 R91 N93 Y94 E95 L97 S98 K99 R100
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gzx, PDBe:6gzx, PDBj:6gzx
PDBsum6gzx
PubMed30301898
UniProtP0DOY7|RS17_THET8 Small ribosomal subunit protein uS17 (Gene Name=rpsQ)

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