Structure of PDB 7pwo Chain Q1 Binding Site BS01

Receptor Information
>7pwo Chain Q1 (length=125) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVHTLGKKKNSVAVAFVKAILVNNVPLALVRPEILRTKVSEPIMILGLDM
NIKVAGGGHVSQIYAVRQAISRGVLASVKDEAARSELRAKLVSYDRQLVV
SDPRRCEAKKFGGRGARARRQKSYR
Ligand information
>7pwo Chain 2 (length=1355) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccggucgauccugccggagcgcgacgcucuccccaaggacgaagccau
gcaugccucaggacgcggcggacggcucaggacaacgguugcaccccccg
uggcggucgccggacaccgcuggcaacccggcgccaagacgugcgcgcaa
gggcgggccccgggcgagcagcgugacgcagcgacggcccgcccgggcuu
ccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgc
cuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcc
cgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgc
gcggcggcgcgacggggugcgcgcgagucaggcgggcccaccccgacccg
ccagggcaaggcuggugccagcagccgcgguaauuccagcucggcgagcg
ucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgcc
acgaggaaacgggagcgcuccaggcagguuggacccgccgcgugggaccg
cggcgggcccggcgcgccgcggcagccccgaggagagcgggcgggggcac
cgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccg
gccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggcc
gggggcuagaaggcgaucagacaccaccguauucccggccguaaacggug
ccgccccgcggccggcgcgcgucccgccggccgcccagggaaaccgggag
gcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcau
ugacggagggguacaccagacguggagucugcggcucaaucugacucaac
gcgcgcaccucaccaggcccgcgcgguggugcauggccgcucccagcccg
uggcgcgagccgugcuccauugcgacaacgagcgagaccccggccgcggg
ccgcgggacggcccgcagcgggaggacggcggggcgauagcaggucugug
augcccuccgcccugggccgcacgcgcgcuacacuggcggggccagccgg
cgcccgcgaggacgcgagcccccgccguggccgggaccgcgggcuggaac
gcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgcc
ggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugg
gcgcugcggcgagcgccccggacgggaagggccgcgagccccagcgccug
gaggaaggagaagucguaacaagguauccguaggugaaccugcggaugga
ucccu
..<<<<<.[..(((>>>>>.<<<<<<<<<..<<<....<......<<<.<
<<..<<<.........>>>......<<........<<<..<<..<<...<
<<<<......<<.....<<<<<<....>>>>>>......>>.....<<..
..<<<.......<.....>..>>>...>>.......>.>>>>..>>>>..
>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>
>>>.<.<<....>>.>...>>>>>>.........<<<....<<<...>>>
..>>>..>.....>>>..........<<<.<<.........>>.>>>..<
<<.<(((...<<<<<.....<<.)))>>.......>>>>>>.>>>..>>>
>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<
<<<.......<<..<<.......>>........>>.....>>>>>..>.>
>><<<<<<.......>>>.>.>>..........<<<<<<<.....<<<<.
.<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>....
...<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<
<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<
<<.<<..<<<<<<<<<<.<...>.>>>>>>>>>>...<<..))>>....>
>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]
<<<<<.<<<<<<<.<<.<<<<<<..<<<.<<<<<<......<<.......
.>>.........<<<<<.<.....<<.<<<..<<.<<<<<<....<<.<<
<<<<....>>>..<<......>>....>>>.>>....<<<<<.<<<<<<.
>>>>>>.....<<<<<.>>>>>.......>>>>>....>>>.>>>.....
>>>>>>>..>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<
<<.<<....>>.>>>....>>>>>>>......<....<<.<<<<......
>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<
<<<<<<.<<<..<<<.<<<.........>>>.>>>..>>>.>>>>>>>>.
..>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>...
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pwo Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		K31 K32 N33 A88 G89 G90 G91 H92 V93 S94 R129 V133 R137 R138 C139 E140 K142 K143 F144 G148 A149 R150 R153 Q154 K155 S156 Y157
Binding residue
(residue number reindexed from 1)		K8 K9 N10 A55 G56 G57 G58 H59 V60 S61 R96 V100 R104 R105 C106 E107 K109 K110 F111 G115 A116 R117 R120 Q121 K122 S123 Y124
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwo, PDBe:7pwo, PDBj:7pwo
PDBsum7pwo
PubMed35100413
UniProtA8BKC6

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