Structure of PDB 7ttw Chain Q Binding Site BS01

Receptor Information

>7ttw Chain Q (length=64) Species: 1280 (Staphylococcus aureus)

PKMKTHRGAAKRVKRTASGQLKRSRAFTSHLFANKSTKQKRQLRKARLVS
KSDMKRVKQLLAYK

Ligand information

>7ttw Chain 1 (length=2690)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acuucagacaaacuccgaaugccaauuaauuuaacuugggagucagaaca
ugggugauaagguccguguucgaaagggaaacagcccagaccaccagcua
aggucccaaaauauauguuaaguggaaaaggauguggcguugccacagag
ugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugug
gauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcau
gaucguaaggacauguggagcgcuuagaagugagaaugccggugugagua
gcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagag
gaaggcucguccgcucuggguuagucggguccuaagcugaggccgacagg
cguaggcgauggauaacagguugauauuccuguaccaccuauaaucguau
cgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgu
cuaagcaguaaggcugccgguagcugagcugugauggggagaagaccuuc
gagucguugauuucacacugccgagaaaagccucuagauagaaaauaggu
gcccguaccgcaaaccgacacagguagucaagaugagaauucuaagguga
gcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgg
gagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauag
gcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggu
gauguauaggggcugacgccugcccggugcuggaagguuaagaggagugg
uuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaa
cuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccc
gcacgaaaggcguaacgauuugggcacugucucaacgagagacucgguga
aaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagac
cccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccg
caccacuuaucguggugggagacagugucaggcgggcaguuugacugggg
cggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaug
guuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgag
accuacaagucgagcagggucgaaagacggacuuagugauccggugguuc
cgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaaca
ggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucga
ugucggcucaucgcauccuggggcuguagucggucccaaggguugggcug
uucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacag
uucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuu
aguacgagaggaccgggauggacauaccucugguguaccaguugucgugc
caacggcauagcuggguagcuauguguggacgggauaagugcugaaagca
ucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaa
gaucccucaaagaugaugagguuaauagguucgagguggaagcaugguga
cauguggagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<......
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>........>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<.>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<
<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<.<.<<........
>>.>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>
><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<
<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......
<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>
>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<
<...<<<<....<<<<...<<...<....<.<<<.........>>>.>.<
....<<<<...<<<........>>>...>>>>.....>.....<....>.
.......>....>>...>>>>.........>>>>..>>......>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>.
.<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>
.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>
.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<
<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<<.....>>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>..
...>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......
<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<..>.>>>>....<<.
<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<....
.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<
<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.(
(..>>>>..))>>>>>>>.............>>>>..]]>>>>.......
<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.....
..<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<..
...>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>
>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.
..............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<...
...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<.......
....>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....
<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....
>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ttw A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): P2 K3 M4 K5 H7 R8 K12 R13 T17 A18 S19 K23 R24 A27 F28 S30 H31 F33 N35 K39 Q40 R42 R45 R57 Q60 Y64
• Binding residue (residue number reindexed from 1): P1 K2 M3 K4 H6 R7 K11 R12 T16 A17 S18 K22 R23 A26 F27 S29 H30 F32 N34 K38 Q39 R41 R44 R56 Q59 Y63

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ttw, PDBe:7ttw, PDBj:7ttw
• PDBsum: 7ttw
• PubMed: 35736238
• UniProt: Q2FXQ0|RL35_STAA8 Large ribosomal subunit protein bL35 (Gene Name=rpmI)