Structure of PDB 7sym Chain Q Binding Site BS01

Receptor Information
>7sym Chain Q (length=115) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLSRGLRRKQHSLLKRLR
KAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEM
IGHYLGEFSITYKPV
Ligand information
>7sym Chain 2 (length=1697) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucuugggagcggccguccccugcucggcgccggcccgaagc
guuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucgga
acugaggccaugauuaagagggacggccgggggcauucguauugcgccgc
uagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauu
ugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagac
gaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugc
ggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaaguc
uuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuu
ggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaaca
cgggaaaccucacccggcccggacacggacaggauugacagauugauagc
ucuuucucgauuccgugggugguggugcauggccguucuuaguuggugga
gcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaac
uaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguu
cagccacccgagauugagcaauaacaggucugugaugcccuuagaugucc
ggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacg
ccggcaggcgcggguaacccguugaaccccauucgugauggggaucgggg
auugcaauuauuccccaugaacgaggaauucccaguaagugcgggucaua
agcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuac
uaccgauuggaugguuuagugaggcccucggaucggccccgccggggugc
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[[(((.>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<.....<....<<<<.........<<.....<<.<<<....
.>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><...<<<<<...<......>..>>>>>.......>...<<<<.<<<
<.>>>>>>>>..>.>>>...>...>.>>>.<<<....<<<.....<<<<<
<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....
.<<.<<<<...<<....>>....>>>>..>>.......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>
..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>....
..>.>>...>>>........<.<..<<<<<<<...............>>>
>>>>..>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<.
..<<<......>>>......>>>>>>>>..>>.......<<....>>...
>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<
<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<
<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.
....>>>.>.>.<<<......<<<<....>>>>....>>>...))).]].
<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........
>>..........<<<<<......<<<<<<.......<<.<<<........
>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<..
<...>.>...<<<......>>>...>>.>>>....<<<.......<<<<.
.<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>........<<<<<...
..>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>
>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<
<<....>>>>.>>>....>.........>>>.>>......<.....<<<<
<..........>>>>>.....>.....>>>>>.....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>..>.......<.....<..<<<
<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<<..>
>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>
...>......>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sym Comprehensive structural overview of the HCV IRES-mediated translation initiation pathway
Resolution4.8 Å
Binding residue
(original residue number in PDB)		R18 S38 A39 R40 R42 R43 R44 R47 K52 L56 R59 K77 T78 H79 R81 D82 Y97 N98 G99 K100 E118 T122 Y123 V126
Binding residue
(residue number reindexed from 1)		R7 S27 A28 R29 R31 R32 R33 R36 K41 L45 R48 K66 T67 H68 R70 D71 Y86 N87 G88 K89 E107 T111 Y112 V115
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000056 ribosomal small subunit export from nucleus
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7sym, PDBe:7sym, PDBj:7sym
PDBsum7sym
PubMed
UniProtG1U0Q2|RS15_RABIT Small ribosomal subunit protein uS19 (Gene Name=RPS15)

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