Structure of PDB 7q08 Chain Q Binding Site BS01

Receptor Information

>7q08 Chain Q (length=118) Species: 237561 (Candida albicans SC5314)

FKQFSFKGVDLKDLVEMPTEEFTKLCGARVRRRFSRGLDSKPMGLIKKLR
AARAATEPNERPAVVKTHLRNMIVVPEMIGSVVGVYNGKVFNTVEIKPEM
VGHYLGEFSITYTPVRHG

Ligand information

>7q08 Chain 1 (length=3209)

ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcg
gaggaauguggcacggcuucugcuguguguuauagccucugacgauacug
ccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaauga
ucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugc
gaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugg
gggcccauuagggugcaccaucgaccgauccugauguguucggauggauu
ugaguaagagcauagcuguugggacccgaaagauggugaacuaugccuga
auagggugaagccagaggaaacucugguggaggcucguagcgguucugac
gugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaac
caucuaguagcugguuccugccgaaguuucccucaggauagcagaagcuc
guaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaa
ugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcu
uaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugg
uaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccg
gaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagc
cggacgguggccauggaagucggaauccgcuaaggaguguguaacaacuc
accggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuac
uuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcg
uggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucu
agugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaga
cugaaguggggaaagguuccaugucaacagcaguuggacauggguuaguc
gauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggc
caaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauu
cuucacggcaacguaacugaauguggagacgucggcgugagcccugggag
gaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccg
gagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggu
gcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugcc
aagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguu
gauagaauaauguagauaagggaagucggcaaaauagauccguaacuucg
ggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgc
gaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugg
uacggacaaggggaaucugacugucuaauuaaaacauagcauugugaugg
ucagaaagugauguugacacaaugugauuucugcccagugcucugaaugu
caaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaug
acucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaug
aauggauuaacgagauucccacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguu
gagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaa
gcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcga
uccggguugaagacauugucagguggggaguuuggcuggggcggcacauc
uguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaa
ucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagug
ugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaa
uuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuugug
gcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcu
cuuccuaucauaccgaagcagaauucgguaagcguuggauuguucaccca
cuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuu
uacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagag
gaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacg
ccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaa
uccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacg
aauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuu
agcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgc
ggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaag
caguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugu
cugauuugu

.......................<<<<<<.....<......>......>>
>>>.>.........<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.
....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<....<<<<
...>>>>....>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<
<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>
>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>
>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<
..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<
..<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>
>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<.
.......>>>>.>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<
...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<....
.>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<.
.....>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.
....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.
....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<
<<<.<<....<<.........>>....>>.........<<......>>..
.>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>
>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.
<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>
>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<
<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<
<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>
......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.
....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<
<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>
....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.
..>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>
>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>
..<<<<.....<<<<<<<.<<...............<<<<<.........
......>>>>><<.<<<<<<<<<<<..<.<<<.<......<<<.<<...<
..>..>>.>>>.......>>>>..>.......>>>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<
.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......
>>>>>>........<...........<<<<<.......>>>>>.....>.
....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>.
...<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<
<<<<<..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<....
.<<<<..<<<<<......>>>>>..............<<<<...>>>>..
>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<......
.>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.)))
)))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>
>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<............
.....>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>
>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...
>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<.....
.....<<<<....>>>>......>>.......<<<<<<...<<<<<<<..
<<<......>>>..>>>>>>>.>>>>>>................>>>.>>
>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<
<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>
..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7q08 E-site drug specificity of the human pathogen Candida albicans ribosome.
• Resolution: 2.56 Å
• Binding residue (original residue number in PDB): R72 V75
• Binding residue (residue number reindexed from 1): R61 V64

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000054 ribosomal subunit export from nucleus
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7q08, PDBe:7q08, PDBj:7q08
• PDBsum: 7q08
• PubMed: 35613268
• UniProt: A0A1D8PK22|RS15_CANAL Small ribosomal subunit protein uS19 (Gene Name=RPS15)