Structure of PDB 7aav Chain Q Binding Site BS01

Receptor Information
>7aav Chain Q (length=138) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRI
HHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCC
LRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCR
Ligand information
>7aav Chain 6 (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauccccugcgcaaggaug
<<<<<.<<....>>>>>>>...............................
.........<<<.....>>>...
Receptor-Ligand Complex Structure
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PDB7aav Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R41 G96 T111 N112 T115 N116 C117 I118 P122 K125 C134
Binding residue
(residue number reindexed from 1)		R39 G94 T109 N110 T113 N114 C115 I116 P120 K123 C132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016922 nuclear receptor binding
GO:0030374 nuclear receptor coactivator activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:2000825 positive regulation of androgen receptor activity
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aav, PDBe:7aav, PDBj:7aav
PDBsum7aav
PubMed33243851
UniProtP41223|BUD31_HUMAN Protein BUD31 homolog (Gene Name=BUD31)

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