Structure of PDB 6ywv Chain Q Binding Site BS01

Receptor Information

>6ywv Chain Q (length=353) Species: 367110 (Neurospora crassa OR74A)

MDKLLRRVRMAEGMVARRAQRKNALLKRITERKQNKKNGEAFTEAIQQRK
AAVEARNEDWMLGPLAPRRELDEITLSNGNFFGSLSPTRALLESEVSEEE
RKARVAWCGSPKFLCIAPGDRVVVIEGHHKDLIGTIEKLNTRNMTVEIQS
EKLKTNTTVPQFMQNDADKPVTQIYARLPISSVRLVHPLKDPQTGEYRDV
IIRELRPRNIVHDRPTRTRSMRRFVPGENIIIPWPKQEPIKREDQPADTL
RIDVDEKTFVPTLFRPPAPQQVLDELRNKYSIFRTRHTPEYIAKKEQEEQ
EKEAKKSAAKAMLTPVQEYNRKQRELRRARGQPALTEEMLAKIGEVVARN
KLG

Ligand information

>6ywv Chain A (length=2529)

guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagag
acuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuua
uguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaa
uaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaa
cgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaa
guaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaag
gcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuu
ugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcgua
ccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuaga
ugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuag
acccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacg
gguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagac
aacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaa
uuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguag
auuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucgggguu
aucggugaguauguagacucggaaugacaaagaugaaucuugaauaauca
gacauagaaugauaagguuguaugucaaaagggaaacagcccagaacaag
aguuaagguuccaaaauuauuauuaagugaaauaaagaaaguuuuuauau
aagucgacaagaagaugggcuuggaagcagccauaauuuaaagaucucgu
aacagagcacuuguuaaaucuuaaaagcaucgaaaauuuaacggaucuaa
auaauauaccgaaaccuuguccauauguaacauuaguaauaauauuaaug
uuauuugaugggguagcagaacguugagugaaucuuagauuuuuuuuuua
uaacuaaauauagaugauaacucaagugagaauggugacaugaguaacaa
aaaagaguuuaagguaccuaaaagguaucuuagagucucgccuaaagcuu
auggcuacgucaaguaacggccucuaaguuuauaaucugaagauuaugac
gaugagaaaacuuugguaccaacauuuaaaagugaaaauugugcaggaag
gauaaaccguaccuagaaucugaaacaaguaagcuaguagagaauacgaa
ggcgugaaugagauaacaaucauaaaggaacucggcaaacuauaccguaa
cuuagggauaaggagagcauggaauauuguuguacgacuguuuaauuaaa
acaaagcacuuugcaaaaagacgauaagucuaaguauugagugugauuuc
auguaacgauacaacagcugucucuaugauugacucagugaaauuggaau
aacugugcagauacaguuuaccucuaguuagacgagaagacccuaugcag
cuuuacuguuacuaauuauugaauacgaaucguauuauuaaaccuuaaau
uaaggaacaauuguuagaagacaguuuaggccccauaaagaguaaauggg
ugugucuaaaauguuugcaauuuuuuauaguauauaucaaaucaucuuua
ugcuauucauggguacaguauaaaaauuuaagaaauuagguaagauuuug
uuuauagagaaauuagauguaaaaaaaaaaucuuaugagggcggauccgc
uucuaauauuuuuuuguaguuauuauuauaauaauaaucauguuuauuac
uuaaaaagcuuaauggcuuaaucuugccuuacuguuugauuaacaacaaa
ucuuacagucgcguaagcggggcauaggaucacaagauacaaaaaggaaa
gaucuuggauuuuuggaaaagcuacgcuagggauaacaggcuaauuugcg
caagaguguacaaaaugagugcgcgguuuggcaccucgaugucggcuuga
cuaauccucauggaugcagaaacuauguaggguacgacuguucgucgauu
aaaaaguuacaugagcuggguuaaauacgucgugagacaguaugguuucu
aucuucuagagggaauuagaauauaauaaggauuaaccuuuguacgaaag
gaacaugggguacuauuguuauauaacaguuuuauuaaccucugguuuac
cuguuguuuaugugccuuagggauguuaccgucacuugaguaaauacaau
agcauaagcauggcaggaaagcuaaguuagucaaaaauaagugcugaaag
cauauaggcacgaaauuuaccuuaagauauuucuuaaauauacguaagaa
aauauuacguuaauaggcuuaguuuguaaggaacuaaguacuaauuuuau
aaaaaacugaaugauuaauauaucuuaca

<<<<..<<<<<<.......<<<<<<<<<..>>>>...<<<.......<<<
<<<<<<<......<<.....<<<<<<<<<.<<<<<<.....>>.....<<
<<<<................>>>>>>....>>>>..<<....>>......
....<<<<<<.....<......>......>>>>>.>.........<<...
.>>..<<<<<<.....<<....>>....>>>>>>..<<............
...<<<<<<<<....>>>>>>>>........<<<<<..[[[[>>>>>...
>>......>>>>>>>>>.................<<....>>....>>..
.....>>>>>>>>>>.......<<<<..<<.........>>..>>>>...
<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<.......
..>>>...<......>..<<<<<.....>>>>>...>>>>>>>>>>>>>.
.<<.<..<<<<<<<....<<<<<<<<<<..<<<<<....>>.>>>...<<
<..<<<<........>>>>.>>>....>>>>>>>>>>....<<.....>>
.......>>>>>>.>..>.>>..<<<<<<....<<<<<....>>>>>..<
<<<<<<...<<<<<<.<<.....<<<......<<<<<<.<<<<<<<.<.<
..<<<<<<<<<..>>>>>>>>>>>.>>>.....>>>>.....<<<<<..>
.>>>>>>>>.>>.....>>.>.....>>.>>>>>>...>>>>>>>.....
<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<<<
.<<...<<<(((.....<<<<<<.....<<......<<..<<<<<<<...
.....<<<<<<.<....<<<<.......>>>>....>........<<<..
....>>>..>>>>>>......>>>>>>>.>>...........)))>>...
>>>>>>.>>>...>>>>>>><<<<..<<<<<<<<<<<<....>>>>>>>>
>>>>...>>>>....>>>>>>..<<<<<<..<<<....<<..<<..<<..
.>>..>>..>>....>>>.>>>>>>........>>>>>><......<<..
...<<<.<<<<<<<<<<<.....>>>>>>>>>>>.>>><<<<<...<<<<
<.<<........((...<<<.<<<...<<<.<<<<<<<..>>>>>>>>>>
...>>>....)).........<<<.<<..(((((..>>.>>>........
......>>>..>>......<<......>>>>>>>..<<<.....>>>..>
>>>>....<<<<....<<<<<<<<.<<.................<<....
<<..>>.....>>..............<<<<<<<<<..<<<.........
>>>..<<<<<<.......<<<<.....>>>>.......>>>>>>....<.
>.....>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....
<<<<<........>>>>>..<<<<<<<..<<<.<<...<<<<<<<.<<<<
<<..<<<<<..<<<<<.<<..<<<<<<<.>>>>>>>......<<<<....
.>>>>....>>.>>>>>...>>>>>....<<<<<<...........>>>>
.>>..<<.....<.......<<<..<<<<...>>>>..>>>.>.......
...<<<<<..>>>>>.......................<<<<<<<.....
<<<<.........>>>>.<<<<..<<<<<<<.<<<.<<.<<<<<..>>>>
>>>>>>.>>>.>>>>...<<<<<<<<<..>>>>>>>>>........>>>>
......<<<...(((>>>...>>>>>>>...<<<<..<<<.........>
>>..>>>>.<<<....>>>.>>))).......<<<<<<.<...]]]]...
>>>>>>>............>>>>..>>>>>>>......<<<<.....<<<
<<...<.........>...>>>>>.....>>>.>.>>......<<<..<<
<<...<<<<<<<<.........>>>>>..>>>..<<<<.....>>>>...
....>>>>......>>>.......<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>.....<<<<<<...<<<<<...<<<<............
......>>......<<<<<<<<>>>>>>>>>>.<<<<<<...<<<<...<
<<<<<<<<<<<<<.<<<..>>>...<<<<...)))))..>>>>.......
.>>>>>>>>>..>>>>>...>>>>.>>>>>>..<<<.<..<<<<<.....
......>>>>>...>>>>.>>>>>...>>>.>>>....<<<.<<<<<...
....>>>>>....<<<<<<<<<<<<....>>.>>>>>>>.>>>.....>>
>....>>>>>>>>.....>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ywv Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
• Resolution: 3.03 Å
• Binding residue (original residue number in PDB): M10 E12 M14 R17 R18 R21 N23 L26 K27 R28 I29 R32 K36 F42 T43 R49 K50 R56 K112 F113 P207 N209 I210 H212 R214 R217 T218 R219 S220 R222 W234 Q237 P239 I240 R242 L276 R277 N278 K279 Y280 S281 I282 F283 R284 H287 T288 Y291 Y319 N320 R321 R324 R327 R328 G331 Q332
• Binding residue (residue number reindexed from 1): M10 E12 M14 R17 R18 R21 N23 L26 K27 R28 I29 R32 K36 F42 T43 R49 K50 R56 K112 F113 P207 N209 I210 H212 R214 R217 T218 R219 S220 R222 W234 Q237 P239 I240 R242 L276 R277 N278 K279 Y280 S281 I282 F283 R284 H287 T288 Y291 Y319 N320 R321 R324 R327 R328 G331 Q332

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005840 ribosome

External links

• PDB: RCSB:6ywv, PDBe:6ywv, PDBj:6ywv
• PDBsum: 6ywv
• PubMed: 33056988
• UniProt: Q7RXU7|RM40_NEUCR Large ribosomal subunit protein uL24m (Gene Name=mrpl40)