Structure of PDB 6yhs Chain Q Binding Site BS01

Receptor Information

>6yhs Chain Q (length=102) Species: 575584 (Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841)

AKIKKGDQVIVIAGKEKGKQGTVLSVSEDRVKVEGLNLVKKHQKPNRVTG
AEGGIVTQEASLHISNVAILNATTQKADRVGYQVIDGVKTRVYKSTGESV
AV

Ligand information

>6yhs Chain 1 (length=2672)

gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaug
aaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuu
gauccggagaugucugaaugggggaacccaccuacuuuaagguagguauu
gcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacauc
ucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcga
gcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucu
gggaagugcgaacguagagggugauauucccguacacgaaagggcacaca
uaaugaugacgaguagggcgaggcacgugaaaccuugucugaauaugggg
ggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccagu
accgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauc
cugaaaccgcaugcauacaagcagugggagcaccuuuguggugugacugc
guaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaac
cguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugc
uggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguu
ggguaacacuaacuggaggaccgaacccacugucguugaaaagccagggg
augacuuguggauaggggugaaaggcuaaucaagccuggugauagcuggu
ucuccccgaaagcuauuuagguagcgccucggacgaauaccauagggggu
agagcacuguuucggcuaaccgaugcaaacuccgaauaccuaugaguacu
auccgggagacagacugcgggugcuaacguccguagucaagaggaaaaca
auccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgau
gugggaaggcaagucggccugcgcggaagauguaacggggcuaaaacuau
gugccgaagcugcggauguauacuuuguauacgugguaggggagcguucu
guaagccgaugaagguguguugagaagcaugcuggagguaucagaagugc
gaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaa
agaccaaggguuccaguccaacguuaaucggggcugggugagucgacccc
uaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccau
uacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggc
guugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgg
gguacucuaugcugagaucugaaagugguugaugccaugcuuccaggaaa
agucucuaagcuucaguuacacaggaaucguacccgaaaccgacacaggu
ggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacu
aggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugau
ugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaa
acauagcacucugcaaacacgaaaguggacguauagggugugaugccugc
ccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugau
cgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcga
aauuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcg
gcgcugucuccagcagaggcucagugaaaucgaaaucgcugugaagaugc
aguguacccgcggcuagacggaaagaccccgugaaccuuuacugcagcuu
gacacugaacugguucuaacucugucccgugauccgggacgaggaccgug
ucugguggguaguuugacuggggcggucuccuccuaaagaguaacggagg
aguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaag
gcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaagu
aggucuuagugauccggugguucuguauggaagggccaucgcucaacgga
uaaaagguacucuggggauaacaggcugauaccgcccaagaguucauauc
gacggcgguguuuggcaccucgaugucggcucaucucauccuggggcuga
agcaggucccaaggguauggcuguucgccauuuaaagagguacgcgagcu
ggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcug
gaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaac
cucugguguaccgguugugacgccagucgcaucgccggguagcuauguuc
ggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagaua
agauuucccuaggacuuuauguccucuaaagagccguucgagacuaggac
guugauagguuggauguggaagcauagugauaugugaagcugaccaauac
uaauugcucgugaggcuugacu

<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<....
..<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>...
..>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<
<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>
......>>>>>.>.........<<....>>...<<<<<.....<<.....
>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<.
.....>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>
>>>>...........<<<<<<<<.........>>>>>>>>......<<<<
<..<<<<>>>>>..>>>......]].>>>>>>>.]]..............
.<<....>>....]].........<<<<.....>>>>.............
.....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<
<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>
>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<
<<......>>>>>>.>...>>>...<<<.<<<.<........>.>>>>>>
....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>.
.<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<....
.<<<...<<<.<<<<....>>>>.>>>..>>.>.....>>>>>>.>>>..
.>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<.....
.>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..
<<<<<..<<....>>..>>>>>.>>...........)))......>>>>>
>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<
<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.
....>>>>>><......<<.....<<<<<<.......>>>>>><<<<...
.<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<
...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>
>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<.
..((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>
>>>>>....>>>>...>>>>.....>>>>>...>>>...>>>.>......
..>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>
>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.....
....<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<...
...>>>>>>>>>>>>............<<<<<<<<<..<<<.........
>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<
<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>....
...>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...
........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>
>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>
>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.
<<<<<.<<<<..>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>
>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>
>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((
>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>
>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.........
....>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>
...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<..
....>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>
.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<
<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<
...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>
>...<<<....<<<<<...........>>>>>....>>>.>>>>......
.>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>
>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>
>>...>>>>..>..>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yhs Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): K5 K16 V27 V40 K42 H43 K45 P46 G55 H64 S66 N67 R80 Y83 K90 K95
• Binding residue (residue number reindexed from 1): K4 K15 V26 V39 K41 H42 K44 P45 G54 H63 S65 N66 R79 Y82 K89 K94

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6yhs, PDBe:6yhs, PDBj:6yhs
• PDBsum: 6yhs
• PubMed: 32857965
• UniProt: D0CD08