Structure of PDB 6tps Chain Q Binding Site BS01

Receptor Information

>6tps Chain Q (length=461) Species: 559292 (Saccharomyces cerevisiae S288C)

TFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDETRRLNLT
TNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILK
RQIRWLITEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTIS
ILYLASTHLSLPVYTCDYIKWICTAKMPYFQASEILPKSWRIQLPNYYVS
ILEGSISPFNGQLYNKIALTCGMIHFKEFFNSEISCQGLLLKLVMQCALP
PEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSNHAELRVLSYFMLT
INWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDKPTS
SDYFQWSEEETLEFLKWMEKQFLPTQTDQKIARRKLYKIFPLDSTHQLTF
IEDLQERYAKQTPFFPPARKEAIGRLLTHIASQLLVDFAISKEQLKDCIS
RIKNACLHRMN

Ligand information

>6tps Chain S (length=27)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 6tps Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting.
• Resolution: 3.54 Å
• Binding residue (original residue number in PDB): V212 S213 E216 S218 E292 R504
• Binding residue (residue number reindexed from 1): V199 S200 E203 S205 E279 R451

Gene Ontology

Molecular Function

• GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0017025 TBP-class protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0001188 RNA polymerase I preinitiation complex assembly
• GO:0006360 transcription by RNA polymerase I
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I

Cellular Component

• GO:0000120 RNA polymerase I transcription regulator complex
• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0070860 RNA polymerase I core factor complex

External links

• PDB: RCSB:6tps, PDBe:6tps, PDBj:6tps
• PDBsum: 6tps
• PubMed: 32139698
• UniProt: P40992|RRN7_YEAST RNA polymerase I-specific transcription initiation factor RRN7 (Gene Name=RRN7)