Structure of PDB 6elz Chain Q Binding Site BS01

Receptor Information

>6elz Chain Q (length=134) Species: 559292 (Saccharomyces cerevisiae S288C)

HRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSV
SRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKI
VKAGGECITLDQLAVRAPKGQNTLILRGPRNSRE

Ligand information

>6elz Chain 1 (length=2457)

guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaau
aagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaa
gcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguugua
auuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaac
aggacgucauagagggugagaaucccguguggcgaggagugcgguucuuu
guaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugg
gugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaagu
acagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacg
ugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguu
uugguggcaggauaaauccauaggaauguagcuugccucgguaaguauua
uagccugugggaauacugccagcugggacugaggacugcgacguaaguca
aggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaa
ggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaau
gaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauc
cugaggauggauuugaguaagagcauagcuguugggacccgaaagauggu
gaacuaugccugaauagggugaagccagaggaaacucugguggaggcucg
guucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacu
aaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcaga
agcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggcca
uuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaa
ggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucu
agacagccggacgguggccauggaagucggaauccgcuaaggagugugua
acaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagc
guguuaccuauacucuaccgucaggguugauaugaugcccugacgaguag
gcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaac
ggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacu
uugaagacugaaguggggaaagguuccacgucaacagcaguuggacgugg
guuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuu
augcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggau
auggauucuucacgguaacguaacugaauguggagacgucggcgcgagcc
cugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauuggu
uuauccggagauggggucuuauggcuggaagaggccagcaccuuugcugg
cuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuu
ucaugccaggucguacugaggucuccaaggugaacagccucuaguugaua
gaauaauguagauaagggaagucggagggucggacgaucaacuuagggaa
ucugaacgagauucccacugucccuaucuacuaucuagcgaaaccacagc
caagggaacgggcuuggcagaaucagcggggacccuguugagcuugacuc
uaguuugacauuauugucagguggggaguaaaguuaccacagggauaacu
ggcuuguggcagucaagcguucauagcgacauugcucggcucuuccuauc
auaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggg
aacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacu
gaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguuc
auucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagc
uaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcua
gaacgcggugauuucuuugcuccacacaauauagauggauacgaauaagg
cguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuugg
cggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcgugg
ggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagca
guagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucu
gauuugu

..........................<<<<<<.....<......>.....
.>>>>>.>...<.....<<....>>..<<<<<......<<.....>>...
..>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>......
..>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......
>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>..
..>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<
<<<<..>>>>>>..>>>....>............................
.<<....>>...............<<<<....>>>>..............
....................<<<<<.<<<<<<.....<<<<<<<.<<<<<
<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>....
...>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.
....>>>>>>>....>>>>>>.>>>>>..<<<<.<....>.>>>><<<<<
<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<
....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<.<<<<
<.......>>>.>>..>>....>>>>>>.>>>>>>..<<.<..<<<<<<<
...<<<<<<<<<....<<<....<<<<<<<....>>>>>>>.....>>>.
<.<<.<<........>>>>.>........>>>>>>>>>.<<<....>.>>
...>>>>>>>.....>.>>..<<<<<<..................<<<<<
<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<
.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<
<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<....<<.........>>....>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>
>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>
>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>
>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>
>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>
....((<<<<<<...<<....<<<....>>>........<<<<<<.....
...>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<
<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<
<<<<<<<<<<...((..>>>>>><...<<<<<....<<<<<<....<<<.
....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>
>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>>
.>>>>>>>>>>>>..>>....>>>>>.<<<<.....>>>>..>>>>..<<
<<.....<<<<<<<.<<.........<<<<<<..>>>>>...>..<<<<<
<<<....>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....<<<<<..<<..<<<<<.<<<<<<<.<<<<
<.<<<<<<<<....>>>>>>>>..>>>>>.>>>>>..>>>>>>>......
........<<<<<...<<.......>>...>>>>>..<<<..<<<<<..<
.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>
>......>>>.......<<<<<<<....>>>.>>>>.........>>.>>
>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>
>.><<<<<...<<<<...<<<<<<<<<<<))..>>>>>..>>>>>>..>>
>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>
....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<
<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<
<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>
>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<
.....<<<<........>>>>....>>>...>>>....>>>>.>>>>>..
>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6elz Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): K20 S21 K31 F35 R38 R39 P43 F44 K50 L54 S55 K56 N58 P61 S63 S65 R66 R69 Q73 K79 T86 T88 D89 D90 R92 I93 R105 T107 A108 Q135 N136 T137 I139 L140 R141 G142 P143 R144 N145 R147
• Binding residue (residue number reindexed from 1): K6 S7 K17 F21 R24 R25 P29 F30 K36 L40 S41 K42 N44 P47 S49 S51 R52 R55 Q59 K65 T72 T74 D75 D76 R78 I79 R91 T93 A94 Q121 N122 T123 I125 L126 R127 G128 P129 R130 N131 R133

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6elz, PDBe:6elz, PDBj:6elz
• PDBsum: 6elz
• PubMed: 29245012
• UniProt: P0CX49|RL18A_YEAST Large ribosomal subunit protein eL18A (Gene Name=RPL18A)