Structure of PDB 6az3 Chain Q Binding Site BS01

Receptor Information
>6az3 Chain Q (length=189) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSLKLQARLASSILGCGRARVWLDPNEAVEIQNANSRKSVRKLIKDGFII
RKPVKVHSRARWRKMKEAKDMGRHNGVGRREGSREARMPSKELWMRRLRI
LRRLLRKYRADKKIDRHVYRDLYVRAKGNVFRNKRNLVEHIHKIKNEKKK
ERQLAEQLAAKHLRDEQNRNKARKQELRKREKERERARR
Ligand information
>6az3 Chain 1 (length=1620) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguggcagguauuugucugccaaagu
uaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaagu
uugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaa
agacaauggaaguaccuccauuucaacggccagaaccagcccuacugcau
uauccugucgggggucaaaauccggcgggcaagaagugcaagaagggucu
uggugaaaugagcggaguauuugagcugugcacggcgcgcacgcacucuu
cuccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuu
gaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugguu
gccaguacuuucucguacugaaagggagaugcaaaaugcaucuguggugu
gcacacgucauuugcccaacaccgaccggcccuccguggguugcguugga
gugugccuguuuggacccgaaagguggugaacuaugccugaacaagguga
agcccggggaaacccagguggaggccuguagcgaugcugacgugcaaauc
gcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuagua
gcugguucacaucgaaguuucccucaggauagcuggugcuaguagaagua
uugugcgguaaagcaaaugauuagaggcauugggaccuauucucaaacuu
uaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaa
gaauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugc
ggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucu
cgauacguaaaggguguugguggauauccaccggccccgaaaauggauga
cgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaa
acaaaggagaaaguguagcccuuccgauguagauguggccuggagguuag
gacgaagcuuauggcgugagccuaagauggaccggccucuagugcagauc
uugguuggcguagcaaagaucuaacggagauauacucaacaugcaacguu
ggauacuggagcggggaaggauuucgugccaacggcacucguacacgagu
uguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaagg
uggucggccauaacugaaaaggggcaacagagaaccugggauuauauucc
aaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>
....................................<<....>>......
..........<<<......>>>............................
......(((..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<<...<<<<
...<<<<<<<<<........>>>>>>>>>.....>.>>>....>>>>>..
>>>>........<<<<<.....<<...<<<<.<<...>>...>>>>>>..
>>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<...
.....>>>><<<<<<...<<<<<<<<.<<<<<..<<<.<<<<.<......
......>>>>>>>>...<<....>>..<<<<<.....>>>>>...<<<<<
...<<.<...>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...
>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...
<<<<<<<...<<<....<<<....<<<...<..>.>>>....>>>..>.>
>...>>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>........
...>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<
<<......>>>>..<<<<<<<...<<<(((......<..<<<<.......
.<.........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))
).>....>>>>.>.........>>>...>>>>>>>((((.<<<<<.....
.....>>>>.........>>>>>))))....>>>>>....<<<<<<<<..
.......<<<..<<<....>>>.>>>.......>>>>>>>>........>
>>>>>..............<<<<<<<....................>>>>
>>>....................<<<<<....<<.....>>..>>>>>..
..<<..........<<.<<<<<......>>>>............<..<<.
<..........>.>>..>...>.>>..........<<<<.........>>
....>>.>>...........
Receptor-Ligand Complex Structure
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PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		V2 L4 L6 R9 L10 R19 W23 L24 P26 R38 R42 K53 E86 K92 W95 V125 K128 G129 N130
Binding residue
(residue number reindexed from 1)		V1 L3 L5 R8 L9 R18 W22 L23 P25 R37 R41 K52 E85 K91 W94 V124 K127 G128 N129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtA0A504XXD2

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